Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 3/20 | 0.38 |
| ▸ | QDPR | P09417 | 2/20 | 0.47 |
| ▸ | KDM5C | P41229 | 6/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 6/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | KDM4A | O75164 | 4/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31704656 | 1.00 | QDPR (0.47) | QDPRKDM5CKDM4CKDM3AKDM2A | |
| SCHEMBL31706313 | 0.84 | KDM4E (0.54) | QDPRKDM5CKDM4CKDM3AKDM2A | |
| SCHEMBL31705749 | 0.84 | KDM4E (0.54) | QDPRKDM5CKDM4CKDM3AKDM2A | |
| Lithium Ion SCHEMBL25269674 | 0.75 | KDM5C (0.61) | KDM5CKDM4CKDM3AKDM2AKDM4E | |
| Lithium Ion SCHEMBL31705789 | 0.74 | QDPR (0.51) | QDPRWNT3ANAMPTALDH1A1SMN1; SMN2 | |
| Lithium Ion SCHEMBL31706510 | 0.74 | QDPR (0.51) | QDPRWNT3ANAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15025632 | 0.74 | CCR1 (0.49) | QDPRWNT3ANAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28956035 | 0.73 | QDPR (0.47) | QDPRWNT3ACCNT1CDK9NAMPT | |
| SCHEMBL30282328 | 0.73 | QDPR (0.47) | QDPRWNT3ACCNT1CDK9NAMPT | |
| SCHEMBL28374030 | 0.73 | KDM5C (0.63) | KDM5CKDM4CKDM3AKDM2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |