Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705789 | 1.00 | QDPR (0.51) | QDPRNAMPTCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL31705303 | 0.87 | QDPR (0.53) | QDPRNAMPTCYP11B2CYP11B1ALDH1A1 | |
| Lithium Ion SCHEMBL31705494 | 0.85 | JAK1 (0.44) | NAMPTALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31704634 | 0.85 | JAK1 (0.44) | NAMPTALDH1A1GAAALOX15TSHR | |
| SCHEMBL31704818 | 0.84 | QDPR (0.51) | QDPRNAMPTCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL13778394 | 0.83 | QDPR (0.57) | QDPRNAMPTCYP11B2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31704850 | 0.82 | NAMPT (0.42) | NAMPTALDH1A1GAAALOX15TSHR | |
| Lithium Ion SCHEMBL31705374 | 0.82 | NAMPT (0.42) | NAMPTALDH1A1GAAALOX15TSHR | |
| SCHEMBL4163298 | 0.81 | QDPR (0.54) | QDPRNAMPTCYP11B2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31705772 | 0.74 | QDPR (0.47) | QDPRNAMPTALDH1A1SMN1; SMN2WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |