Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 16/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31704541 | 1.00 | NAMPT (0.39) | NAMPTJAK1JAK2TYK2KDM4E | |
| SCHEMBL31705068 | 0.85 | NAMPT (0.40) | NAMPTJAK1JAK2TYK2 | |
| SCHEMBL31706013 | 0.85 | NAMPT (0.40) | NAMPTJAK1JAK2TYK2 | |
| Lithium Ion SCHEMBL31705930 | 0.80 | NAMPT (0.36) | NAMPTJAK1JAK2TYK2KDM4E | |
| Lithium Ion SCHEMBL31704844 | 0.79 | NAMPT (0.40) | NAMPTJAK1JAK2TYK2KDM4E | |
| Lithium Ion SCHEMBL31705481 | 0.77 | NAMPT (0.41) | NAMPTKDM4EUSP2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31705457 | 0.77 | NAMPT (0.41) | NAMPTKDM4EUSP2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31706711 | 0.76 | NAMPT (0.40) | NAMPTKDM4EUSP2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31705492 | 0.76 | NAMPT (0.40) | NAMPTKDM4EUSP2ALDH1A1GAA | |
| Lithium Ion SCHEMBL31704965 | 0.75 | MAPT (0.34) | NAMPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |