Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 6/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31705008 | 1.00 | MAPT (0.34) | MAPTTDP1MEN1NPC1RAB9A | |
| SCHEMBL31706914 | 0.88 | CNR2 (0.36) | DGAT2TNKSTNKS2NAMPTCNR2 | |
| SCHEMBL31704919 | 0.84 | CHRM4 (0.39) | MEN1KMT2ANAMPTCNR2ALDH1A1 | |
| SCHEMBL31705447 | 0.84 | CHRM4 (0.39) | MEN1KMT2ANAMPTCNR2ALDH1A1 | |
| Lithium Ion SCHEMBL3799858 | 0.79 | MAPT (0.47) | MAPTTDP1MEN1NPC1RAB9A | |
| Lithium Ion SCHEMBL31705153 | 0.79 | PIM1 (0.35) | TNKSTNKS2NAMPT | |
| Lithium Ion SCHEMBL31706584 | 0.78 | MAPT (0.40) | MAPTTDP1MEN1NPC1RAB9A | |
| Lithium Ion SCHEMBL31705451 | 0.78 | MAPT (0.40) | MAPTTDP1MEN1NPC1RAB9A | |
| Lithium Ion SCHEMBL31705638 | 0.77 | DGAT2 (0.35) | DGAT2TNKSTNKS2NAMPTALDH1A1 | |
| Lithium Ion SCHEMBL31706463 | 0.77 | DGAT2 (0.35) | DGAT2TNKSTNKS2NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |