SCHEMBL31707010

SCHEMBL31707010

CON(C)C(=O)c1cc2nc(Cl)ccc2n1COCC[Si](C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.38
F11 P03951 1/20 0.35
DGAT1 O75907 1/20 0.34
MAPT P10636 1/20 0.33
PTGER4 P35408 1/20 0.31
KMT2A Q03164 1/20 0.31
KDM4E B2RXH2 1/20 0.31
KLKB1 P03952 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30552644 0.85 NPC1 (0.41) NPC1F11DGAT1MAPTKMT2A
SCHEMBL31706595 0.83 EGFR (0.35) NPC1F11MAPT
SCHEMBL30204407 0.82 CCR9 (0.39) NPC1F11DGAT1MAPTKMT2A
SCHEMBL31453156 0.81 NPC1 (0.39) NPC1MAPTPTGER4KMT2AKDM4E
SCHEMBL31705877 0.79 TUBB4A (0.39) NPC1
SCHEMBL22774174 0.78 NPC1 (0.38) NPC1F11DGAT1MAPT
SCHEMBL16920131 0.78 NPC1 (0.38) NPC1F11DGAT1MAPTPTGER4
SCHEMBL31710775 0.74 NPC1 (0.38) NPC1F11MAPTKMT2AKDM4E
SCHEMBL31609619 0.74 NPC1 (0.37) NPC1F11MAPTKMT2A
SCHEMBL30552872 0.74 NPC1 (0.37) NPC1F11MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025215558-A1 COMPOUNDS FOR SPLICING MODULATION FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2025-10-16 WO disclosed