Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DNM1L | O00429 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ILK | Q13418 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728413 | 0.94 | HTR2B (0.48) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Hydrochloric Acid SCHEMBL31122121 | 0.93 | CHEK1 (0.47) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Phosphoric Acid SCHEMBL31122117 | 0.89 | CHEK1 (0.47) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Succinic Acid SCHEMBL31122141 | 0.86 | CHEK1 (0.43) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Cadaverine Tartrate SCHEMBL31122154 | 0.85 | CHEK1 (0.42) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Cadaverine Tartrate SCHEMBL31122127 | 0.85 | CHEK1 (0.42) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL3952859 | 0.81 | ALDH1A1 (0.54) | CHEK1ACHEALDH1A1DNM1LHPGDS | |
| Citric Acid SCHEMBL31122150 | 0.80 | CHEK1 (0.41) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL31122153 | 0.80 | CHEK1 (0.48) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL31122128 | 0.78 | CHEK1 (0.47) | CHEK1ALDH1A1DNM1LHPGDSGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326778-A1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | RIGEL PHARMACEUTICALS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326778-A1 | PYRAZOLE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS | IRAK3, IRAK1, IRAK2 | CHEK1 414/4885HTR2B 4061/4885CYP2C19 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.