Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DNM1L | O00429 | 2/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL31122154 | 1.00 | CHEK1 (0.42) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL2728413 | 0.91 | HTR2B (0.48) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Hydrochloric Acid SCHEMBL31122121 | 0.89 | CHEK1 (0.47) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Succinic Acid SCHEMBL31122141 | 0.86 | CHEK1 (0.43) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Formic Acid SCHEMBL31708359 | 0.85 | CHEK1 (0.44) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| Phosphoric Acid SCHEMBL31122117 | 0.85 | CHEK1 (0.47) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL3952859 | 0.81 | ALDH1A1 (0.54) | CHEK1ACHEALDH1A1DNM1LHPGDS | |
| Citric Acid SCHEMBL31122150 | 0.80 | CHEK1 (0.41) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL31122153 | 0.80 | CHEK1 (0.48) | CHEK1HTR2BCYP2C19ACHECYP2C9 | |
| SCHEMBL31122128 | 0.75 | CHEK1 (0.47) | CHEK1ALDH1A1DNM1LHPGDSGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119301121-A | Pyrimidin-2-yl-pyrazole compounds as IRAK inhibitors | 里格尔药品股份有限公司 | 2025-01-10 | — | — | CN | claimed |
| CN-119301121-A | Pyrimidin-2-yl-pyrazole compounds as IRAK inhibitors | 里格尔药品股份有限公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-118510771-A | IRAK inhibitors for the treatment of conditions associated with cytokine release associated with respiratory viral infection | 里格尔药品股份有限公司 | 2024-08-16 | — | — | CN | disclosed |