Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390399 | 0.89 | GPR119 (0.71) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3170627 | 0.86 | GPR119 (0.56) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3159956 | 0.86 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3170405 | 0.84 | GPR119 (0.52) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3170510 | 0.83 | GPR119 (0.57) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3169807 | 0.81 | GPR119 (0.56) | GPR119CYP2C9KCNH2 | |
| SCHEMBL6065686 | 0.81 | GPR119 (0.46) | GPR119CYP2C9ERBB2 | |
| SCHEMBL6456096 | 0.81 | GPR119 (0.54) | GPR119CYP2C9ERBB2KCNH2 | |
| SCHEMBL3164182 | 0.79 | GPR119 (0.58) | GPR119CYP2C9ACACBKCNH2 | |
| SCHEMBL3160646 | 0.78 | GPR119 (0.57) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-B9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1644357-B1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-12 | — | — | EP | claimed |