Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6066173 | 0.83 | GPR119 (0.46) | GPR119TTKCYP2C9 | |
| SCHEMBL390399 | 0.82 | GPR119 (0.71) | GPR119CYP2C9 | |
| SCHEMBL3170975 | 0.81 | GPR119 (0.56) | GPR119ERBB2CYP2C9 | |
| SCHEMBL6456096 | 0.75 | GPR119 (0.54) | GPR119ERBB2CYP2C9 | |
| SCHEMBL4475518 | 0.73 | ERBB2 (0.74) | ERBB2 | |
| SCHEMBL5050653 | 0.70 | GPR119 (0.39) | GPR119CYP2C9 | |
| SCHEMBL5046463 | 0.69 | GPR119 (0.55) | GPR119CYP2C9 | |
| SCHEMBL30775255 | 0.69 | CYP2C19 (0.56) | CYP2C19LRRK2TBK1 | |
| SCHEMBL12236467 | 0.68 | HRH1 (0.43) | GPR119 | |
| SCHEMBL20375579 | 0.68 | CYP1A2 (0.44) | ALDH1A1CYP1A2MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007647-A1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | disclosed |