Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553755 | 0.87 | FGFR1 (0.67) | SMN1; SMN2FGFR1KMT2AHTTDAPK3 | |
| SCHEMBL3163264 | 0.84 | FGFR1 (0.49) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL6661733 | 0.84 | NPSR1 (0.57) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL6663533 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL6663303 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL3163635 | 0.80 | SMN1; SMN2 (0.77) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL3178190 | 0.76 | FGFR1 (0.43) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL3163540 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL6641941 | 0.73 | HTT (0.40) | SMN1; SMN2MAPTFGFR1KMT2AHTT | |
| SCHEMBL6641938 | 0.71 | CCR1 (0.42) | SMN1; SMN2MAPTFGFR1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
| US-7576080-B2 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | MEMORY PHARMACEUTICALS CORPORATION | 2007-11-08 | — | — | US | disclosed |
| EP-1831229-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006071988-A1 | THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORP. (US) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010017-A1 | CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | PDE12, PDE4A, PDE7A | SMN1; SMN2 2966/4885MAPT 1972/4885FGFR1 3524/4885 |
| US-20070259896-A1 | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors | PDE12, PDE7A, PDE7B | SMN1; SMN2 2680/4885MAPT 1474/4885FGFR1 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.