Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6663303 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL6661733 | 0.84 | NPSR1 (0.57) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL4553755 | 0.84 | FGFR1 (0.67) | SMN1; SMN2LMNAKMT2AMEN1CSNK2A2 | |
| SCHEMBL3172318 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL2369140 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL3163264 | 0.76 | FGFR1 (0.49) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL14975573 | 0.73 | PRKCI (0.55) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL6832453 | 0.71 | KMT2A (0.57) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL3178190 | 0.71 | FGFR1 (0.43) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL3163540 | 0.70 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138238-A1 | Substituted aminopyrimidine compounds as neurokinin antagonists | PREDIX PHARMACEUTICALS HOLDINGS, INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004014850-A2 | SUBSTITUTED AMINOPYRIMIDINES AS NEUROKININ ANTAGONISTS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138238-A1 | Substituted aminopyrimidine compounds as neurokinin antagonists | TACR1, GRPR, BDKRB1 | SMN1; SMN2 1992/4885MAPT 1853/4885LMNA 3508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.