SCHEMBL31725296

SCHEMBL31725296

Nc1ncnc2c1c(F)cn2[C@@H]1O[C@](F)(CO)[C@@H](F)[C@H]1O

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 7/20 0.47
▸ WDR77 Q9BQA1 6/20 0.47
▸ ADK P55263 12/20 0.47
▸ DOT1L Q8TEK3 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ GALR3 O60755 1/20 0.42
▸ S1PR4 O95977 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ S1PR1 P21453 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ PAX8 Q06710 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31228253 0.91 ADK (0.51) PRMT5WDR77ADKDOT1LNPC1
SCHEMBL26239618 0.80 ADORA3 (0.57) PRMT5WDR77DOT1L
SCHEMBL25390968 0.80 ADORA3 (0.57) PRMT5WDR77DOT1L
SCHEMBL25388043 0.80 ADORA3 (0.57) PRMT5WDR77DOT1L
SCHEMBL31228180 0.79 ADK (0.50) PRMT5WDR77ADKDOT1LNPC1
SCHEMBL31228437 0.79 ADK (0.50) PRMT5ADKDOT1LNPC1GALR3
SCHEMBL31228211 0.77 ADK (0.59) PRMT5WDR77ADKDOT1LNPC1
SCHEMBL31228230 0.77 ADK (0.48) PRMT5WDR77ADKDOT1LNPC1
SCHEMBL31228248 0.77 ADK (0.60) PRMT5WDR77ADKDOT1LNPC1
SCHEMBL13146109 0.76 ADK (0.45) PRMT5WDR77ADKDOT1LNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025235664-A1 PURINE NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO EMORY UNIVERSITY (US) 2025-11-13 — — WO disclosed
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