SCHEMBL31726486

CC(C)[C@H](NC(=O)[C@H](CCCC(=O)OC(C)(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)Nc1ccc(COC(=O)Oc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	PTPN1	P18031	3/20	0.37

▸	MDM2	Q00987	1/20	0.37

▸	SIRT5	Q9NXA8	3/20	0.37

▸	SIRT2	Q8IXJ6	6/20	0.36

▸	SIRT1	Q96EB6	5/20	0.36

▸	SIRT3	Q9NTG7	3/20	0.36

▸	PSMB8	P28062	1/20	0.36

▸	PSMB9	P28065	1/20	0.36

▸	PSMB5	P28074	1/20	0.36

▸	TGM2	P21980	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29423538	0.93	MDM2 (0.39)	MDM2SIRT5SIRT2SIRT1SIRT3
SCHEMBL17541276	0.92	PTPN1 (0.38)	PTPN1MDM2SIRT5SIRT2SIRT1
SCHEMBL17550383	0.92	PTPN1 (0.38)	PTPN1MDM2SIRT5SIRT2SIRT1
SCHEMBL30831284	0.91	PTPN1 (0.42)	PTPN1MDM2PSMB5
SCHEMBL30288542	0.90	PTPN1 (0.42)	PTPN1MDM2SIRT5
SCHEMBL17541309	0.90	KLK7 (0.38)	PTPN1MDM2SIRT2SIRT1SIRT3
SCHEMBL31726487	0.87	MDM2 (0.43)	MDM2SIRT5SIRT2SIRT1SIRT3
SCHEMBL31727026	0.85	MDM2 (0.43)	PTPN1MDM2SIRT5
SCHEMBL17550420	0.85	PSMB5 (0.39)	PTPN1SIRT5SIRT2SIRT1SIRT3
SCHEMBL29723475	0.85	FURIN (0.40)	PTPN1SIRT2SIRT1SIRT3PSMB5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2025235686-A1	FLUOROCAMPTOTHECIN COMPOUNDS, CONJUGATES, AND METHODS THEREOF	Aarvik Therapeutics, Inc. (US)	2025-11-13	—	—	WO	disclosed