Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406030 | 0.78 | PTGDR2 (1.00) | PTGDR2CYP2C9AKR1B1 | |
| SCHEMBL1385122 | 0.77 | PTGDR2 (0.87) | PTGDR2CYP2C9AKR1B1 | |
| SCHEMBL5310742 | 0.76 | PTGDR2 (0.60) | PTGDR2CYP2C9AKR1B1 | |
| SCHEMBL5313741 | 0.75 | PTGDR2 (0.54) | PTGDR2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL1758007 | 0.75 | PTGDR2 (0.62) | PTGDR2PTGS1 | |
| SCHEMBL27520426 | 0.75 | KDM4E (0.72) | PTGDR2AKR1B1 | |
| SCHEMBL21032471 | 0.74 | PTGDR2 (0.57) | PTGDR2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL3372368 | 0.74 | PTGDR2 (0.76) | PTGDR2CYP2C9AKR1B1 | |
| SCHEMBL5310737 | 0.74 | PTGDR2 (0.56) | PTGDR2CYP2C9AKR1B1PTGS1 | |
| SCHEMBL27605874 | 0.73 | PTGDR2 (0.65) | PTGDR2CYP2C9AKR1B1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093278-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2012-01-10 | — | — | US | disclosed |
| US-20100210685-A1 | Novel Substituted Indoles | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | US | disclosed |
| US-7754735-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2010-07-13 | — | — | US | disclosed |
| US-20050222201-A1 | such as 3-(2-chloro-4-quinolinyl)-2,5-dimethyl-1H-indole-1-acetic acid, used for treating respiratory system disorders and as inhibitors of G protein-coupled receptor chemoattractant homologous receptor expressed on lymphocyte cells (CRTH2) | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
| EP-1549634-A1 | NOVEL SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003101981-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210685-A1 | Novel Substituted Indoles | IDO1, IDO2, TPH1 | PTGDR2 429/4885CYP2C9 378/4885AKR1B1 324/4885 |
| US-20050222201-A1 | such as 3-(2-chloro-4-quinolinyl)-2,5-dimethyl-1H-indole-1-acetic acid, used for treating respiratory system disorders and as inhibitors of G protein-coupled receptor chemoattractant homologous receptor expressed on lymphocyte cells (CRTH2) | HRH2, HRH1, HCAR2 | PTGDR2 54/4885CYP2C9 3502/4885AKR1B1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.