SCHEMBL31731637

SCHEMBL31731637

Cn1c(=O)n(C2CCC(=O)N(COCC[Si](C)(C)C)C2=O)c2cccc(N)c21

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 1/20 0.33
▸ CRBN Q96SW2 1/20 0.33
▸ NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30990759 0.89 DDB1 (0.33) DDB1CRBNNPC1
SCHEMBL30990774 0.89 DDB1 (0.33) DDB1CRBN
SCHEMBL31731627 0.86 PIK3CA (0.31) DDB1CRBN
SCHEMBL31160833 0.85 HCRTR1 (0.33) DDB1CRBN
SCHEMBL30990800 0.84 JAK2 (0.32) DDB1CRBN
SCHEMBL30990736 0.84 DDB1 (0.32) DDB1CRBN
SCHEMBL30990664 0.82 — —
SCHEMBL30990713 0.82 HCRTR1 (0.30) —
SCHEMBL31731259 0.82 DDB1 (0.36) DDB1CRBNNPC1
SCHEMBL31731298 0.82 DDB1 (0.30) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606533-B2 3-phenylpropylamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-04-21 — — US disclosed
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-11-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE SF1, SF3A1, SFXN1 DDB1 1201/4885CRBN 2290/4885NPC1 2279/4885
US-12606533-B2 3-phenylpropylamine derivative SF3A1, SF1, HTR1D DDB1 363/4885CRBN 2904/4885NPC1 1729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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