Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leuprolide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR known ✓ | P30968 | 2/20 | 0.84 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.87 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.78 |
| ▸ | APLNR | P35414 | 5/20 | 0.65 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leuprolide SCHEMBL570851 | 1.00 | ABCC2 (0.87) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL177978 | 1.00 | ABCC2 (0.87) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL847084 | 1.00 | ABCC2 (0.87) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Deslorelin SCHEMBL1649660 | 0.99 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL10061885 | 0.99 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL21540132 | 0.99 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL4585 | 0.99 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL7751433 | 0.99 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL4414320 | 0.98 | ABCC2 (0.84) | ABCC2GNRHRPTGS1APLNRCXCR4 | |
| Leuprolide SCHEMBL3915060 | 0.98 | GNRHR (0.86) | ABCC2GNRHRPTGS1APLNRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 70524 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056884-A | Methods of treating pancreatic cancer | 坎莫森特里克斯公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260132141-A1 | PROTEIN PHOSPHATASE 2A ACTIVATORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2026-05-14 | — | — | US | claimed |
| EP-4735045-A2 | OXAZAPHOSPHORINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE | La Life Products, LLC (US) | 2026-05-06 | — | — | EP | claimed |
| US-20260115305-A1 | LINKERS, CONJUGATES AND APPLICATIONS THEREOF | GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-20260109699-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2026-04-23 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260077056-A1 | LINKER-PAYLOAD COMPOUND, CONJUGATES AND APPLICATIONS THEREOF | GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) | 2026-03-19 | — | — | US | claimed |
| EP-4709378-A1 | COMPOUNDS FOR NOS-RELATED CANCERS AND METHODS OF USE | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2026-03-18 | — | — | EP | claimed |
| EP-0275404-B1 | LHRH ANALOG FORMULATIONS | ABBOTT LABORATORIES (US) | 1993-04-21 | — | — | EP | claimed |
| WO-1992018107-A1 | METHODS AND FORMULATIONS FOR USE IN INHIBITING CONCEPTION AND IN TREATING BENIGN GYNECOLOGICAL DISORDERS | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 1992-10-29 | — | — | WO | claimed |
| EP-0510731-A1 | LHRH Analog formulations | ABBOTT LABORATORIES (US) | 1992-10-28 | — | — | EP | claimed |
| EP-0474787-A1 | A PROCESS FOR TREATING INFERTILITY AND AN AGENT FOR USE IN THE PROCESS. | NOVO NORDISK AS (DK) | 1992-03-18 | — | — | EP | claimed |
| US-5032109-A | Drug delivery | DRUG DELIVERY SYSTEMS INC. (US) | 1991-07-16 | — | — | US | claimed |
| WO-1990014839-A1 | A PROCESS FOR TREATING INFERTILITY AND AN AGENT FOR USE IN THE PROCESS | NOVO NORDISK A/S (DK) | 1990-12-13 | — | — | WO | claimed |
| WO-1990008553-A1 | TRANSDERMAL DRUG DELIVERY COMPOSITION | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | claimed |
| US-4897256-A | AEROSOLS | ABBOTT LABORATORIES (US) | 1990-01-30 | — | — | US | claimed |
| US-4851211-A | AEROSOL WITH LIOPHILIC COUNTERION WATER, ETHYL ALCOHOL AND PROPELLANT; BIOABSORPTION | ABBOTT LABORATORIES (US) | 1989-07-25 | — | — | US | claimed |
| EP-0275404-A1 | LHRH analog formulations | ABBOTT LABORATORIES (US) | 1988-07-27 | — | — | EP | claimed |