Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 4/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465276 | 0.90 | LMNA (0.62) | LMNAPLA2G10PLA2G2AFFAR1ALOX15 | |
| SCHEMBL3172714 | 0.86 | LMNA (0.54) | LMNAPLA2G10PLA2G2APPARDFFAR1 | |
| SCHEMBL420401 | 0.85 | ALOX15 (0.68) | LMNAPLA2G10PLA2G2APPARDFFAR1 | |
| SCHEMBL7028743 | 0.81 | PPARA (0.60) | PPARDFFAR1PPARGPPARATSHR | |
| SCHEMBL18165300 | 0.79 | FFAR1 (0.67) | FFAR1TSHRSMN1; SMN2NR4A2MRGPRX4 | |
| SCHEMBL3169425 | 0.79 | FFAR1 (0.55) | LMNAPLA2G10PLA2G2APPARDFFAR1 | |
| SCHEMBL413254 | 0.79 | LMNA (0.81) | LMNAFFAR1ALOX15PPARGPPARA | |
| SCHEMBL2441116 | 0.78 | LMNA (0.55) | LMNAPLA2G10PLA2G2APPARDFFAR1 | |
| SCHEMBL13777297 | 0.78 | TSHR (0.58) | LMNAPPARDFFAR1ALOX15PPARG | |
| SCHEMBL7418117 | 0.78 | PPARA (0.67) | LMNAFFAR1ALOX15PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273745-B2 | Polycyclic acid compounds useful as CRTH2 antagonists and antiallergic agents | ASTELLAS PHARMA INC (JP) | 2012-09-25 | — | — | US | disclosed |
| EP-2094662-B1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC (JP) | 2012-04-11 | — | — | EP | disclosed |
| US-20100009991-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009991-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | HRH2, HRH1, HRH4 | LMNA 4586/4885PLA2G10 1549/4885PLA2G2A 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.