Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716399 | 0.81 | PKM (0.64) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL24845983 | 0.81 | PKM (0.64) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL6716402 | 0.81 | PKM (0.64) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| Hydrochloric Acid SCHEMBL11323327 | 0.80 | PKM (0.67) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL23330366 | 0.78 | NR4A2 (0.51) | KDM4EEGFRHIF1ANR4A2 | |
| Hydrochloric Acid SCHEMBL6435932 | 0.77 | PKM (0.49) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL25354508 | 0.76 | GABRP (0.60) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL22775321 | 0.76 | GABRP (0.60) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL29604446 | 0.76 | GABRP (0.60) | PKMSLC7A5HSD17B10PTGS1KDM4E | |
| SCHEMBL14780595 | 0.76 | GABRP (0.60) | PKMSLC7A5HSD17B10PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | PKM 4530/4885SLC7A5 308/4885HSD17B10 4549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.