Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186075 | 0.84 | CYP2A6 (0.47) | CYP2A6CYP2A13ERN1ALDH1A1TSHR | |
| SCHEMBL30882789 | 0.84 | CYP2A6 (0.47) | CYP2A6CYP2A13ERN1ALDH1A1TSHR | |
| SCHEMBL8964348 | 0.78 | CYP2A6 (0.48) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 | |
| SCHEMBL9756582 | 0.76 | CYP2A6 (0.47) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 | |
| SCHEMBL4401250 | 0.76 | ERN1 (0.52) | CYP2A6CYP2A13ERN1 | |
| SCHEMBL29954002 | 0.76 | ERN1 (0.52) | CYP2A6CYP2A13ERN1 | |
| SCHEMBL27994638 | 0.74 | CYP2A6 (0.45) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 | |
| SCHEMBL14741400 | 0.74 | CYP2A6 (0.45) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 | |
| SCHEMBL143348 | 0.73 | CYP2A6 (0.48) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7671562 | 0.73 | CYP2A6 (0.48) | CYP2A6CYP2A13ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605763-B | Radioprotector compounds and methods involving | PETER MACCALLUM CANCER INSTITUTE (AU) | 2016-03-09 | — | — | CN | disclosed |
| EP-2114896-B1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INST (AU) | 2015-07-22 | — | — | EP | disclosed |
| EP-2114896-B1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INST (AU) | 2015-07-22 | — | — | EP | disclosed |
| US-8796277-B2 | Radioprotector compounds and related methods | PETER MACCALLUM CANCER INSTITUTE (AU) | 2014-08-05 | — | — | US | disclosed |
| US-20100022557-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2010-01-28 | — | — | US | disclosed |
| CN-101605763-A | Radioprotector compounds and methods involving | PETER MACCALLUM CANCER INST (AU) | 2009-12-16 | — | — | CN | disclosed |
| EP-2114896-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | Peter MacCallum Cancer Institute (AU) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008074091-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074091-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022557-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | RAD50, ERCC2, XRCC6 | CYP2A6 2292/4885CYP2A13 3527/4885ERN1 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.