SCHEMBL8964348

SCHEMBL8964348

Cc1ccc(N(C)C)cc1C=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.48
CYP2A13 Q16696 1/20 0.48
ALDH1A1 P00352 9/20 0.45
TSHR P16473 5/20 0.45
MAPT P10636 1/20 0.43
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
GRIA4 P48058 1/20 0.41
KDM4E B2RXH2 2/20 0.41
GAA P10253 1/20 0.41
HSD17B10 Q99714 2/20 0.40
ALOX15 P16050 1/20 0.40
APAF1 O14727 1/20 0.40
MAPK1 P28482 2/20 0.39
TP53 P04637 1/20 0.39
HIF1A Q16665 1/20 0.39
TERT O14746 1/20 0.38
APP P05067 1/20 0.38
PDE3B Q13370 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL143348 0.83 CYP2A6 (0.48) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL2845185 0.79 ALDH1A1 (0.58) ALDH1A1TSHRMAPTKDM4EGAA
SCHEMBL4401250 0.78 ERN1 (0.52) CYP2A6CYP2A13
SCHEMBL3176178 0.78 CYP2A6 (0.47) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL15982250 0.78 CYP2A6 (0.47) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL9756582 0.78 CYP2A6 (0.47) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL29954002 0.78 ERN1 (0.52) CYP2A6CYP2A13
SCHEMBL14741400 0.76 CYP2A6 (0.45) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL27994638 0.76 CYP2A6 (0.45) CYP2A6CYP2A13ALDH1A1TSHRMAPT
SCHEMBL7671562 0.75 CYP2A6 (0.48) CYP2A6CYP2A13ALDH1A1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008137102-A2 METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR TORREYPINES THERAPEUTICS, INC. (US) 2008-11-13 WO disclosed
EP-0465155-B1 Non-linear optical material containing steroidal ketone compound HITACHI CHEMICAL CO LTD (JP) 1996-02-28 EP disclosed
US-5443758-A A ketone cis- or trans-gonanes; nonlinear optical response HATACHI CHEMICAL COMPANY, LTD. (JP) 1995-08-22 US disclosed
US-5262090-A Electrooptical switches HITACHI CHEMICAL COMPANY, LTD. (JP) 1993-11-16 US disclosed
EP-0465155-A2 Non-linear optical material containing steroidal ketone compound Hitachi Chemical Co., Ltd. (JP) 1992-01-08 EP disclosed
US-4368335-A N'-(2,6-Dichloro-4-(substituted-benzylamino)phenyl)-N,N-dimethyl-formamidines AMERICAN CYANAMID COMPANY (US) 1983-01-11 US disclosed
US-4360466-A N'-[2,6-Dichloro-4-(substituted-benzylideneamino)phenyl]-N,N-dimethylformamidines AMERICAN CYANAMID COMPANY (US) 1982-11-23 US disclosed