Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | GPR183 | P32249 | 1/20 | 0.58 |
| ▸ | APLNR | P35414 | 1/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | RAF1 | P04049 | 8/20 | 0.55 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | MUSK | O15146 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13528821 | 0.86 | S1PR1 (0.54) | KDRBRAFMAPK14TNNI3KS1PR1 | |
| SCHEMBL939171 | 0.82 | CDK8 (0.70) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL5568335 | 0.82 | KDR (0.67) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL3166444 | 0.81 | KDR (0.68) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL3181311 | 0.81 | RAF1 (0.70) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL936533 | 0.81 | RAF1 (0.73) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL30462521 | 0.81 | RAF1 (0.73) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL3174272 | 0.81 | RAF1 (0.64) | KDRBRAFMAPK14TNNI3KS1PR1 | |
| SCHEMBL5568243 | 0.80 | KDR (0.58) | KDRBRAFMAPK14TNNI3KSRC | |
| SCHEMBL4933323 | 0.80 | KDR (0.64) | KDRBRAFMAPK14TNNI3KRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652022-B2 | N-(4-(4-(4-hydroxyphenylamino)-pyrimidin-6-yl)-oxyphenyl)-N'-(3-trifluoromethylphenyl)-urea; | NOVARTIS AG (CH) | 2010-01-26 | — | — | US | claimed |
| EP-1511730-B8 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2009-04-08 | — | — | EP | claimed |
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | FLOERSHEIMER ANDREAS | 2006-06-15 | — | — | US | claimed |
| EP-1511730-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2005-03-09 | — | — | EP | claimed |
| WO-2003099771-A2 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2003-12-04 | — | — | WO | claimed |
| US-20130338168-A1 | Combinations of JAK Inhibitors | NOVARTIS AG (CH) | 2013-12-19 | — | — | US | disclosed |
| US-20100280003-A1 | COMBINATIONS OF JAK INHIBITORS | COOKE NIGEL GRAHAM | 2010-11-04 | — | — | US | disclosed |
| US-20090156602-A1 | Organic Compounds | COOKE NIGEL GRAHAM | 2009-06-18 | — | — | US | disclosed |
| US-20080207591-A1 | Organic Compounds | MANLEY PAUL W | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280003-A1 | COMBINATIONS OF JAK INHIBITORS | JAK2, JAK3, JAK1 | KDR 123/4885BRAF 17/4885MAPK14 310/4885 |
| US-20130338168-A1 | Combinations of JAK Inhibitors | JAK2, JAK3, JAK1 | KDR 123/4885BRAF 17/4885MAPK14 310/4885 |
| US-20080207591-A1 | Organic Compounds | FLT4, FLT1, FLT3 | KDR 7/4885BRAF 112/4885MAPK14 2685/4885 |
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | UCK2, PRKDC, PRKACA | KDR 3898/4885BRAF 284/4885MAPK14 444/4885 |
| US-20090156602-A1 | Organic Compounds | BTK, JAK2, JAK3 | KDR 74/4885BRAF 21/4885MAPK14 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.