Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13480673 | 0.98 | APP (0.61) | APPCCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL2136232 | 0.80 | APP (0.68) | APPCCNE1CDK2CDK5CDK5R1 | |
| Iodide SCHEMBL29935453 | 0.78 | KDM4E (0.60) | APPMAPTKDM4EGAANPC1 | |
| SCHEMBL3181929 | 0.78 | APP (0.66) | APPCCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL4593965 | 0.77 | APP (0.94) | APPMAPTKDM4EGAANPC1 | |
| SCHEMBL4799750 | 0.77 | APP (0.68) | APPCCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL29935663 | 0.76 | RAB9A (0.62) | APPMAPTKDM4EGAANPC1 | |
| SCHEMBL1637646 | 0.76 | APP (0.58) | APPCCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL13853343 | 0.75 | APP (1.00) | APPMAPTKDM4EGAANPC1 | |
| SCHEMBL26686965 | 0.75 | APP (0.69) | APPCCNE1CDK2CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655767-B2 | Use of thiazolyl-pyridinium based dyes in optical layers for optical data recording | CLARIANT FINANCE (BVI) LIMITED (VG) | 2010-02-02 | — | — | US | disclosed |
| US-20080108799-A1 | Use Of Thiazolyl-Pyridinium Based Dyes In Optical Layers For Optical Data Recording | CLARIANT FINANCE (BVI) LIMITED (VG) | 2008-05-08 | — | — | US | disclosed |
| EP-1789498-A1 | USE OF THIAZOLYL-PYRIDINIUM DYES FOR OPTICAL DATA RECORDING | Clariant International Ltd. (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024642-A1 | USE OF THIAZOLYL-PYRIDINIUM BASED DYES IN OPTICAL LAYERS FOR OPTICAL DATA RECORDING | CLARIANT INTERNATIONAL LTD (CH) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108799-A1 | Use Of Thiazolyl-Pyridinium Based Dyes In Optical Layers For Optical Data Recording | PNPO, TTL, MT-ND4L | APP 1750/4885CCNE1 3400/4885CDK2 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.