⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949281 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL8363305 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL27748657 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL6651887 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL3175045 | 0.97 | — | — | |
| SCHEMBL7290380 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL6434519 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL28631358 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL6957833 | 0.97 | GPR84 (0.56) | — | |
| SCHEMBL3186368 | 0.97 | GPR84 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107820496-B | Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prevention of hepatitis B virus infections | 豪夫迈·罗氏有限公司 | 2020-11-03 | — | — | CN | claimed |
| EP-3328855-B1 | NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2019-05-15 | — | — | EP | claimed |
| US-10053461-B2 | Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2018-08-21 | — | — | US | claimed |
| EP-3328855-A1 | NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | H. Hoffnabb-La Roche Ag (CH) | 2018-06-06 | — | — | EP | claimed |
| US-20180127416-A1 | NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2018-05-10 | — | — | US | claimed |
| US-9573887-B2 | Naphthalene derivative | DAITO CHEMIX CORPORATION (JP) | 2017-02-21 | — | — | US | claimed |
| WO-2017017042-A1 | NOVEL TETRACYCLIC 4-OXO-PYRIDINE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-02 | — | — | WO | claimed |
| EP-1653960-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN INC (US) | 2008-11-26 | — | — | EP | claimed |
| EP-1653960-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN INC. (US) | 2006-05-10 | — | — | EP | claimed |
| US-20050215526-A1 | Melanin concentrating hormone receptor antagonist | AMGEN, INC. | 2005-09-29 | — | — | US | claimed |
| WO-2005019167-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN, INC. (US) | 2005-03-03 | — | — | WO | claimed |
| US-6287648-B1 | MIXTURE OF POLAR COMPOUNDS HAVING POSITIVE DIELECTRIC ANISTROPY | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-09-11 | — | — | US | claimed |
| US-5770672-A | Catalyst for low temperature cure of blocked isocyanates | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1998-06-23 | — | — | US | claimed |
| EP-0810245-A1 | Catalyst for low temperature cure of blocked isocyanates | ELF ATOCHEM NORTH AMERICA, INC. (US) | 1997-12-03 | — | — | EP | claimed |
| EP-0535588-B1 | A method of imparting durable press properties to cotton textiles without using formaldehyde | OSI SPECIALTIES INC (US) | 1996-02-14 | — | — | EP | claimed |
| US-5310418-A | Cyclic acetal of glutaraldehyde | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1994-05-10 | — | — | US | claimed |
| EP-0535588-A1 | A method of imparting durable press properties to cotton textiles without using formaldehyde | OSi Specialties, Inc. (US) | 1993-04-07 | — | — | EP | claimed |
| CN-105611920-B | Preparation of hydroxy-diphenylmethane derivatives | 泰拉科斯萨普有限责任公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-1046529-A | Carbostyril derivative | OTSUKA PHARMA CO LTD (JP) | 1990-10-31 | — | — | CN | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |