⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122500 | 0.95 | — | — | |
| SCHEMBL7675497 | 0.64 | — | — | |
| SCHEMBL5416293 | 0.64 | ALDH1A1 (0.33) | — | |
| SCHEMBL14875525 | 0.64 | — | — | |
| SCHEMBL2277536 | 0.64 | — | — | |
| SCHEMBL581765 | 0.64 | — | — | |
| SCHEMBL4896655 | 0.64 | — | — | |
| SCHEMBL7090382 | 0.61 | — | — | |
| SCHEMBL17556456 | 0.61 | — | — | |
| SCHEMBL2285696 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3737673-B1 | PROCESS FOR PREPARING HALICHONDRIN MACROLIDES AND ANALOGS THEREOF BY A PRINS REACTION, AND INTERMEDIATES OF THIS PROCESS | EISAI R&D MAN CO LTD (JP) | 2024-03-06 | — | — | EP | disclosed |
| US-20230151022-A1 | PRINS REACTION AND COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES AND ANALOGS THEREOF | EISAI R&D MANAGEMENT CO, LTD. (JP) | 2023-05-18 | — | — | US | disclosed |
| US-11643418-B2 | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of analogs of halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-11542269-B2 | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-01-03 | — | — | US | disclosed |
| CN-114716453-A | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B | 卫材R&D管理有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-109942560-B | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B | 卫材R&D管理有限公司 | 2022-06-17 | — | — | CN | disclosed |
| EP-3689881-B1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | EISAI R&D MAN CO LTD (JP) | 2022-01-12 | — | — | EP | disclosed |
| US-11136335-B2 | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-10-05 | — | — | US | disclosed |
| US-20210188867-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-06-24 | — | — | US | disclosed |
| US-10981929-B2 | — | — | 2021-04-20 | — | — | US | disclosed |
| US-9783549-B2 | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-10-10 | — | — | US | disclosed |
| US-9682931-B2 | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof | UBE INDUSTRIES, LTD. (JP) | 2017-06-20 | — | — | US | disclosed |
| WO-2016179607-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES AND OTHER FRAGMENTS USEFUL IN THE SYNTHESIS OF HALICHONDRIN MACROLIDES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-11-10 | — | — | WO | disclosed |
| US-20160264594-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-09-15 | — | — | US | disclosed |
| EP-3066102-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | Eisai R&D Management Co., Ltd. (JP) | 2016-09-14 | — | — | EP | disclosed |
| EP-3064489-A1 | ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF | Ube Industries, Ltd. (JP) | 2016-09-07 | — | — | EP | disclosed |
| US-20160244407-A1 | ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF | UBE INDUSTRIES, LTD. (JP) | 2016-08-25 | — | — | US | disclosed |
| WO-2015066729-A1 | MACROCYCLIZATION REACTIONS AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF ANALOGS OF HALICHONDRIN B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-05-07 | — | — | WO | disclosed |
| US-20100016319-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. A CORPORATION OF JAPAN (JP) | 2010-01-21 | — | — | US | disclosed |
| EP-1970375-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2008-09-17 | — | — | EP | disclosed |