Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318924 | 0.87 | RAB9A (0.57) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL793414 | 0.81 | RAB9A (0.53) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL15754817 | 0.81 | RAB9A (0.60) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL6983909 | 0.81 | RAB9A (0.56) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL13144514 | 0.80 | MAPT (0.70) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL6224829 | 0.80 | RAB9A (0.61) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL2551417 | 0.80 | HTR2B (0.61) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL3103929 | 0.80 | MAPT (0.56) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL3535303 | 0.80 | PANK3 (0.57) | RAB9ANPC1MAPTNPSR1POLB | |
| SCHEMBL15608747 | 0.79 | ACHE (0.55) | ALDH1A1ACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |