Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NTMT1 | Q9BV86 | 5/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3190613 | 0.91 | CHRNA7 (0.67) | CHRNA7KCNH2CHRNB4CHRNA3HTR3A | |
| Trifluoroacetic Acid SCHEMBL3182857 | 0.85 | CHRNA7 (0.61) | CHRNA7 | |
| Trifluoroacetic Acid SCHEMBL3183006 | 0.82 | CHRNA7 (0.57) | CHRNA7KCNH2HTR3EHTR3BCHRNB4 | |
| Trifluoroacetic Acid SCHEMBL3187879 | 0.82 | CHRNA7 (0.72) | CHRNA7KCNH2CHRNB4CHRNA3HTR3A | |
| Trifluoroacetic Acid SCHEMBL1542595 | 0.82 | CHRNA7 (0.56) | CHRNA7NTMT1HTR3EHTR3BHTR3A | |
| Trifluoroacetic Acid SCHEMBL3187996 | 0.82 | CHRNA7 (0.64) | CHRNA7CHRNB4CHRNA3HTR3A | |
| Trifluoroacetic Acid SCHEMBL3190816 | 0.81 | CHRNA7 (0.55) | CHRNA7NTMT1 | |
| Trifluoroacetic Acid SCHEMBL3180075 | 0.81 | CHRNA7 (0.62) | CHRNA7KCNH2NTMT1CHRNB4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL1542199 | 0.80 | CHRNA7 (0.61) | CHRNA7HTR3EHTR3BCHRNB4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL3179410 | 0.80 | CHRNA7 (0.54) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655657-B2 | Fused bicycloheterocycle substituted quinuclidine derivatives | ABBOTT LABORATORIES (US) | 2010-02-02 | — | — | US | disclosed |
| US-20080064703-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | ABBVIE INC. | 2008-03-13 | — | — | US | disclosed |
| US-20070060588-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | ABBOTT LABORATORIES | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060588-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | CHRNA1, CHRNA7, CHRNA2 | CHRNA7 2/4885KCNH2 197/4885NTMT1 1824/4885 |
| US-20080064703-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | IDO1, IDO2, HTR3C | CHRNA7 144/4885KCNH2 26/4885NTMT1 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.