Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318158 | 0.89 | PTPN1 (0.54) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL27029284 | 0.85 | CDC7 (0.49) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL4192679 | 0.85 | MAPT (0.70) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9975800 | 0.83 | MAPT (0.62) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9825984 | 0.83 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL977550 | 0.83 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1724059 | 0.83 | MAPT (0.65) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL4363783 | 0.82 | MAPT (0.58) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL13355827 | 0.81 | MAPT (0.63) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL2158104 | 0.81 | HPGD (0.64) | MAPTKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9620722-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2017-04-11 | — | — | US | disclosed |
| US-9620722-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2017-04-11 | — | — | US | disclosed |
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-9498483-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2016-11-22 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | NOVARTIS AG (CH) | 2015-08-13 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| US-9040690-B2 | 2,3,5-trisubstituted thiophene compounds and uses thereof | NOVARTIS AG (CH) | 2015-05-26 | — | — | US | disclosed |
| US-20060142347-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) | 2006-06-29 | — | — | US | disclosed |
| CN-1795190-A | Compounds and methods for the treatment or prevention of flavivirus infections | VIROCHEM PHARMA INC (CA) | 2006-06-28 | — | — | CN | disclosed |
| EP-1569929-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF i FLAVIVIRUS /i INFECTIONS | Virochem Pharma Inc. (CA) | 2005-09-07 | — | — | EP | disclosed |
| US-6881741-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-04-19 | — | — | US | disclosed |
| CN-1602308-A | Thiophene derivatives as antiviral agents against flavivirus infections | VIRUS CHEM PHARMA INC (CA) | 2005-03-30 | — | — | CN | disclosed |
| US-20050009804-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) | 2005-01-13 | — | — | US | disclosed |
| WO-2004052885-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VIROCHEM PHARMA INC. (CA) | 2004-06-24 | — | — | WO | disclosed |
| US-20040116509-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | SHIRE BIOCHEM INC. (CA) | 2004-06-17 | — | — | US | disclosed |
| EP-1401825-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | Shire Biochem Inc. (CA) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100851-A2 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | SHIRE BIOCHEM INC. (CA) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009804-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | ZC3HAV1, ZYX, ZFX | MAPT 1641/4885KDM4E 1505/4885ALDH1A1 1591/4885 |
| US-20150224109-A1 | 2,3,5-Trisubstituted Thiophene Compounds and Uses Thereof | TPMT, CYP3A5, CYP11B2 | MAPT 2512/4885KDM4E 2436/4885ALDH1A1 283/4885 |
| US-20060142347-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | HAVCR2, ZC3HAV1, MAVS | MAPT 1458/4885KDM4E 3220/4885ALDH1A1 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.