Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3190223 | 1.00 | LMNA (0.56) | LMNATSHRMGLLMEN1KMT2A | |
| SCHEMBL3456919 | 0.79 | ALDH1A1 (0.58) | LMNATSHRMGLLMEN1KMT2A | |
| SCHEMBL5923333 | 0.77 | MAPT (0.55) | TSHRMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL3194493 | 0.77 | MAPT (0.55) | TSHRMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL5923339 | 0.77 | MAPT (0.55) | TSHRMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL3179689 | 0.76 | HTT (0.49) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL3179702 | 0.76 | HTT (0.49) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL3179696 | 0.76 | HTT (0.49) | MEN1KMT2AMAPTGAASMN1; SMN2 | |
| SCHEMBL3190638 | 0.75 | SMN1; SMN2 (0.59) | MGLLMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3190648 | 0.75 | SMN1; SMN2 (0.59) | MGLLMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655688-B2 | Treating nuclear hormone receptor-associated conditions such as cancer and immune disorders; (3a alpha ,4 alpha ,7 alpha ,7a alpha )-2-(3-Chloro-4-hydroxyphenyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-02-02 | — | — | US | claimed |