Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | BLVRB | P30043 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318118 | 0.88 | PIM1 (0.45) | DHODHSLC9A1PIM1PIM3PIM2 | |
| SCHEMBL318205 | 0.84 | PIM2 (0.44) | DHODHPIM1PIM3PIM2 | |
| SCHEMBL11909058 | 0.79 | PIM3 (0.39) | DHODHPIM1PIM3PIM2 | |
| SCHEMBL11906705 | 0.79 | DHODH (0.45) | DHODH | |
| SCHEMBL11906897 | 0.78 | MAP2K3 (0.44) | DHODHSLC9A1GRK6PIM1PIM3 | |
| SCHEMBL11907324 | 0.77 | KDM4E (0.40) | DHODHPIM1PIM3PIM2HDAC6 | |
| SCHEMBL11907633 | 0.76 | ATR (0.38) | DHODHSLC9A1GRK6CTSAJAK2 | |
| SCHEMBL11906961 | 0.76 | FFAR4 (0.44) | DHODHCTSAEIF4EHDAC6 | |
| SCHEMBL16517562 | 0.75 | AURKA (0.46) | — | |
| SCHEMBL11908119 | 0.74 | TGFBR1 (0.35) | DHODHPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |