Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11907595 | 0.88 | MAP2K3 (0.41) | KDM4EALDH1A1GAAMAP2K3MAPT | |
| SCHEMBL16517562 | 0.86 | AURKA (0.46) | KDM4EALDH1A1PIN1SMN1; SMN2NPC1 | |
| SCHEMBL318118 | 0.84 | PIM1 (0.45) | DHODHNPC1RAB9A | |
| SCHEMBL18652666 | 0.84 | ALDH1A1 (0.50) | DHODHKDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL318205 | 0.83 | PIM2 (0.44) | DHODH | |
| SCHEMBL11906996 | 0.82 | CA1 (0.45) | — | |
| SCHEMBL11909058 | 0.81 | PIM3 (0.39) | DHODHPIN1 | |
| SCHEMBL11908040 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL11907464 | 0.80 | ATR (0.47) | KDM4EALDH1A1SMN1; SMN2NPC1GAA | |
| SCHEMBL11907324 | 0.79 | KDM4E (0.40) | DHODHKDM4EALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174002-B2 | Pyridine derivatives as CFTR modulators | NuBridge BioSciences (US) | 2019-01-08 | — | — | US | disclosed |
| US-9981945-B2 | Pyrimidine derivatives as CFTR modulators | NuBridge BioSciences | 2018-05-29 | — | — | US | disclosed |
| US-9890149-B2 | Isothiazole derivatives as CFTR modulators | NuBridge BioSciences (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170101395-A1 | PYRIMIDINE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| US-20170101403-A1 | ISOTHIAZOLE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| WO-2017045612-A1 | PYRIMIDINE DERIVATIVE PIM KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE PREPARATION | 上海吉铠医药科技有限公司 | 2017-03-23 | — | — | WO | disclosed |
| WO-2017045615-A1 | PYRIDINE DERIVATIVE PIM KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE PREPARATION | 上海吉铠医药科技有限公司 | 2017-03-23 | — | — | WO | disclosed |
| WO-2017045616-A1 | ISOTHIAZOLE DERIVATIVE PIM KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE PREPARATION | 上海吉铠医药科技有限公司 | 2017-03-23 | — | — | WO | disclosed |
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2014-09-04 | — | — | US | disclosed |
| US-8822497-B2 | PIM kinase inhibitors and methods of their use | NOVARTIS AG (CH) | 2014-09-02 | — | — | US | disclosed |
| EP-2132177-B1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101403-A1 | ISOTHIAZOLE DERIVATIVES AS CFTR MODULATORS | CFTR, SCNN1B, SLC10A2 | DHODH 3918/4885KDM4E 4876/4885LMNA 4847/4885 |
| US-10174002-B2 | Pyridine derivatives as CFTR modulators | CFTR, SCNN1B, SLC26A4 | DHODH 3244/4885KDM4E 4752/4885LMNA 4625/4885 |
| US-20140249135-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | DHODH 3326/4885KDM4E 946/4885LMNA 2380/4885 |
| US-20170101395-A1 | PYRIMIDINE DERIVATIVES AS CFTR MODULATORS | CFTR, P2RY11, TYMS | DHODH 653/4885KDM4E 4843/4885LMNA 4781/4885 |
| US-20120208815-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | PIM1, PIM2, PIM3 | DHODH 3326/4885KDM4E 946/4885LMNA 2380/4885 |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | CFTR, SCNN1B, SLC26A4 | DHODH 3184/4885KDM4E 4721/4885LMNA 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.