Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 12/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PTPRC | P08575 | 2/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193527 | 0.82 | PTPN1 (0.64) | PTPN1PTPN2ALDH1A1KDM4EPTPRC | |
| SCHEMBL13926043 | 0.77 | KDM4E (0.71) | PTPN1PTPN2HIF1AALDH1A1KDM4E | |
| SCHEMBL4125992 | 0.77 | PTPN1 (0.56) | PTPN1PTPN2HIF1AALDH1A1KDM4E | |
| SCHEMBL3193712 | 0.75 | KDM4E (0.40) | ALDH1A1KDM4EEGLN1HPGD | |
| SCHEMBL4118782 | 0.73 | PTPN1 (0.61) | PTPN1PTPN2KDM4EPTPRC | |
| SCHEMBL4119852 | 0.73 | PTPN1 (0.61) | PTPN1PTPN2HIF1APTPRC | |
| SCHEMBL4131579 | 0.70 | KDM4E (0.52) | PTPN1PTPN2ALDH1A1KDM4EPTPRC | |
| SCHEMBL3194810 | 0.70 | PTPN1 (0.61) | PTPN1PTPN2ALDH1A1KDM4EPTPRC | |
| SCHEMBL3203066 | 0.70 | EGLN1 (0.47) | ALDH1A1KDM4EEGLN1 | |
| SCHEMBL4120254 | 0.69 | KDM4E (0.68) | PTPN1PTPN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674822-B2 | protein tyrosine phosphatase 1B (PTP1B) modulators; type 2 diabetes, obesity; increasing insulin sensitivity; 1-Carboxymethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid | WYETH (US) | 2010-03-09 | — | — | US | disclosed |
| US-20060135488-A1 | protein tyrosine phosphatase 1B (PTP1B) modulators; type 2 diabetes, obesity; increasing insulin sensitivity; 1-Carboxymethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid | WYETH | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135488-A1 | protein tyrosine phosphatase 1B (PTP1B) modulators; type 2 diabetes, obesity; increasing insulin sensitivity; 1-Carboxymethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid | PTPA, PTPRCAP, PTPRC | PTPN1 22/4885PTPN2 14/4885HIF1A 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.