Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 8/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30974795 | 0.85 | L3MBTL1 (0.45) | CA2KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL25278649 | 0.80 | CA1 (0.47) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL16023210 | 0.80 | CA1 (0.47) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL391944 | 0.80 | CA1 (0.47) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL13257974 | 0.79 | HTR6 (0.53) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL30372578 | 0.78 | L3MBTL1 (0.45) | CA2KDM4EUBE2NL3MBTL1POLB | |
| SCHEMBL25238794 | 0.77 | CA1 (0.50) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL29605064 | 0.76 | CA1 (0.49) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL3678959 | 0.76 | CA1 (0.51) | CA1CA2KDM4EUBE2NL3MBTL1 | |
| SCHEMBL25236043 | 0.75 | CA1 (0.48) | CA1CA2KDM4EUBE2NL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110606848-A | 5-azaindole derivative Bruton's tyrosine kinase inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2019-12-24 | — | — | CN | disclosed |
| US-7659283-B2 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659283-B2 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-09 | — | — | US | disclosed |
| EP-2004645-A2 | PYRROLO(3,2-C) PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| WO-2007095223-A2 | PYRROLO(3,2-C) PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | PACSIN2, MAP3K20, PRKCH | CA1 4029/4885CA2 1557/4885KDM4E 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.