Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20081120 | 0.84 | BTK (0.47) | LTA4HNPC1RAB9ABTKALDH1A1 | |
| SCHEMBL10310199 | 0.82 | LTA4H (0.40) | LTA4HGSTP1NPC1SCN4ARAB9A | |
| SCHEMBL14115594 | 0.77 | BACE1 (0.45) | DYRK1AJAK2 | |
| SCHEMBL14115579 | 0.76 | LRRK2 (0.50) | DYRK1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL15084547 | 0.76 | PARP1 (0.42) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL737913 | 0.75 | LTA4H (0.49) | LTA4HGSTP1NPC1SCN4ARAB9A | |
| SCHEMBL15084554 | 0.74 | EGFR (0.44) | DYRK1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL31409705 | 0.73 | DYRK1A (0.36) | DYRK1APIM1PIM3 | |
| SCHEMBL408642 | 0.72 | SCN9A (0.44) | NPC1RAB9ABTKKDRTEK | |
| SCHEMBL30373371 | 0.71 | CCNE2 (0.42) | NPC1RAB9ANISCHALDH1A1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110606848-A | 5-azaindole derivative Bruton's tyrosine kinase inhibitor and preparation method and application thereof | 药雅科技(上海)有限公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-101848909-A | Pyrrolo [3,2-C ] pyridines useful as protein kinase inhibitors | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| US-7659283-B2 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659283-B2 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659283-B2 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-02-09 | — | — | US | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-09-13 | — | — | US | disclosed |
| WO-2007095223-A2 | PYRROLO(3,2-C) PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213327-A1 | Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases | PACSIN2, MAP3K20, PRKCH | LTA4H 4006/4885GSTP1 3577/4885NPC1 3423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.