Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 3/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3193685 | 1.00 | MAPT (0.38) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3192825 | 0.91 | MAPT (0.36) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3192822 | 0.91 | MAPT (0.36) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3189317 | 0.90 | INSR (0.35) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3189310 | 0.90 | INSR (0.35) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| SCHEMBL5570977 | 0.90 | MAPT (0.36) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| SCHEMBL5570983 | 0.90 | MAPT (0.36) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3196350 | 0.86 | MAPT (0.44) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3196345 | 0.86 | MAPT (0.44) | MAPTL3MBTL1NPC1RAB9AMAPK1 | |
| Bromide SCHEMBL3185634 | 0.81 | MAPT (0.39) | MAPTL3MBTL1NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7658771-B2 | Coloring agents for keratin fibers | THE PROCTER & GABLE COMPANY (US) | 2010-02-09 | — | — | US | claimed |
| US-20090158532-A1 | For the simultaneous lightening and coloring of keratin fibers; oxidizing agent and azo dye such as 2-[{4-[(4,5-dimethyl-1,3-thiazol-2-yl) diazenyl ]phenyl}(ethyl)amino]-N,N,N-trimethylethanaminium bromide | WELLA OPERATIONS US, LLC | 2009-06-25 | — | — | US | claimed |
| US-20070199161-A1 | Coloring agents for keratin fibers | WELLA OPERATIONS US, LLC | 2007-08-30 | — | — | US | claimed |
| WO-2007093943-A1 | COLORING AGENTS FOR KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-23 | — | — | WO | claimed |
| US-7658771-B2 | Coloring agents for keratin fibers | THE PROCTER & GABLE COMPANY (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090158532-A1 | For the simultaneous lightening and coloring of keratin fibers; oxidizing agent and azo dye such as 2-[{4-[(4,5-dimethyl-1,3-thiazol-2-yl) diazenyl ]phenyl}(ethyl)amino]-N,N,N-trimethylethanaminium bromide | WELLA OPERATIONS US, LLC | 2009-06-25 | — | — | US | disclosed |
| US-7513917-B2 | Coloring agents for keratin fibers | THE PROCTER & GAMBLE COMPANY (US) | 2009-04-07 | — | — | US | disclosed |
| US-20070199161-A1 | Coloring agents for keratin fibers | WELLA OPERATIONS US, LLC | 2007-08-30 | — | — | US | disclosed |
| WO-2007093943-A1 | COLORING AGENTS FOR KERATIN FIBERS | THE PROCTER & GAMBLE COMPANY (US) | 2007-08-23 | — | — | WO | disclosed |
| EP-1820536-A1 | Coloring agents for keratin fibers | Wella Aktiengesellschaft (DE) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090158532-A1 | For the simultaneous lightening and coloring of keratin fibers; oxidizing agent and azo dye such as 2-[{4-[(4,5-dimethyl-1,3-thiazol-2-yl) diazenyl ]phenyl}(ethyl)amino]-N,N,N-trimethylethanaminium bromide | KRT18, TPM4, TUBB1 | MAPT 823/4885L3MBTL1 4614/4885NPC1 4812/4885 |
| US-20070199161-A1 | Coloring agents for keratin fibers | KRT18, IK, KRTCAP2 | MAPT 859/4885L3MBTL1 4838/4885NPC1 4178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.