SCHEMBL3194064

SCHEMBL3194064

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nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 12/20 0.37
DPP8 Q6V1X1 11/20 0.37
DPP9 Q86TI2 10/20 0.37
DPP7 Q9UHL4 10/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Threonine SCHEMBL1965719 0.90 DPP8 (0.31) DPP4DPP8DPP9DPP7
SCHEMBL1965723 0.89 DPP4 (0.33) DPP4DPP8DPP9DPP7
SCHEMBL26134964 0.86 DPP4 (0.37) DPP4DPP8DPP9DPP7
SCHEMBL5161688 0.85 DPP4 (0.46) DPP4DPP8DPP9DPP7
SCHEMBL3930248 0.85 DPP4 (0.46) DPP4DPP8DPP9DPP7
SCHEMBL122272 0.84 SLC7A5 (0.44) DPP4DPP8DPP9DPP7
SCHEMBL1537207 0.84 SLC7A5 (0.44) DPP4DPP8DPP9DPP7
Valine SCHEMBL17582481 0.84 SLC7A5 (0.37)
SCHEMBL8712673 0.84 SLC7A5 (0.37) DPP4
SCHEMBL1537395 0.83 ALOX15 (0.43) DPP4DPP8DPP9DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240150752-A1 METHODS AND COMPOSITIONS FOR MUTAGENESIS SCREENING IN MAMMALIAN CELLS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-05-09 US disclosed
US-20240141330-A1 METHODS AND COMPOSITIONS FOR MUTAGENESIS SCREENING IN MAMMALIAN CELLS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-05-02 US disclosed
US-11760775-B2 Steroids and protein-conjugates thereof REGENERON PHARMACEUTICALS, INC. 2023-09-19 US disclosed
WO-2021151891-A1 NOVEL PHYTOENE DESATURASE VARIANTS TO PRODUCE NEUROSPORENE AND/OR ZETA-CAROTENE DEINOVE (FR) 2021-08-05 WO disclosed
US-20210040144-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. 2021-02-11 US disclosed
EP-3737420-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF Regeneron Pharmaceuticals, Inc. (US) 2020-11-18 EP disclosed
WO-2019136487-A2 STEROIDS AND ANTIBODY-CONJUGATES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2019-07-11 WO disclosed
US-8323961-B2 HIV vaccines based on adenoviral vectors encoding Env from multiple clades of HIV THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-12-04 US disclosed
EP-1675613-B1 HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV US GOV HEALTH & HUMAN SERV (US) 2012-05-23 EP disclosed
US-20100111998-A1 HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN 2010-05-06 US disclosed
US-7666427-B2 HIV vaccines based on Env of multiple clades of HIV THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2010-02-23 US disclosed
US-20080286306-A1 HIV vaccines based on Env of multiple clades of HIV GENVEC, INC. 2008-11-20 US disclosed
US-20060275897-A1 HIV vaccines based on Env of multiple clades of HIV DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY 2006-12-07 US disclosed
EP-1675613-A2 HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2006-07-05 EP disclosed
WO-2005034992-A2 HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIF THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2005-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210040144-A1 STEROIDS AND PROTEIN-CONJUGATES THEREOF SERPINA6, NR3C1, NR3C2 DPP4 3149/4885DPP8 2394/4885DPP9 2531/4885
US-11760775-B2 Steroids and protein-conjugates thereof SERPINA6, NR3C1, NR3C2 DPP4 3149/4885DPP8 2394/4885DPP9 2531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.