SCHEMBL31945

SCHEMBL31945

CN(C)c1ccc(Oc2ccc(CN)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ST14 Q9Y5Y6 3/20 0.61
ALDH1A1 P00352 3/20 0.50
TSHR P16473 2/20 0.50
CYP3A4 P08684 2/20 0.50
MAPK1 P28482 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
KEAP1 Q14145 1/20 0.50
NFE2L2 Q16236 1/20 0.50
APP P05067 6/20 0.49
CALM1 P0DP23 1/20 0.44
ALOX15 P16050 2/20 0.44
HSD17B10 Q99714 1/20 0.44
MAOB P27338 1/20 0.42
TP53 P04637 1/20 0.41
SCN9A Q15858 1/20 0.41
KLKB1 P03952 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL295816 0.87 ALDH1A1 (0.64) ALDH1A1TSHRCYP3A4MAPK1TDP1
Hydrochloric Acid SCHEMBL2477512 0.85 ALDH1A1 (0.61) ALDH1A1TSHRCYP3A4MAPK1TDP1
Ammonia Solution, Strong SCHEMBL9177602 0.85 ALDH1A1 (0.61) ALDH1A1TSHRCYP3A4MAPK1TDP1
Hydrochloric Acid SCHEMBL1143427 0.85 ALDH1A1 (0.61) ALDH1A1TSHRCYP3A4MAPK1TDP1
Hydrochloric Acid SCHEMBL2680510 0.83 ALDH1A1 (0.58) ALDH1A1TSHRCYP3A4MAPK1TDP1
SCHEMBL4209153 0.82 ST14 (0.85) ST14KEAP1NFE2L2MAOB
SCHEMBL13018335 0.82 ALDH1A1 (0.65) ALDH1A1TSHRCYP3A4MAPK1TDP1
SCHEMBL13018337 0.82 ALDH1A1 (0.65) ALDH1A1TSHRCYP3A4MAPK1TDP1
SCHEMBL3946527 0.82 ALDH1A1 (0.65) ALDH1A1TSHRCYP3A4MAPK1TDP1
SCHEMBL18664384 0.81 HRH3 (0.64) ALDH1A1TSHRCYP3A4MAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012026495-A1 NOVEL HYDANTOIN DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT 杏林製薬株式会社 (JP) 2012-03-01 WO disclosed