Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1910661 | 1.00 | KMT2A (0.38) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL1910662 | 1.00 | KMT2A (0.38) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL14902673 | 0.85 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL14902674 | 0.85 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL1911109 | 0.81 | ALDH1A1 (0.36) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL1911105 | 0.81 | ALDH1A1 (0.36) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL14902702 | 0.79 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL1910649 | 0.76 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL327657 | 0.76 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL1911116 | 0.75 | MEN1 (0.36) | KMT2AMEN1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |