Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1910649 | 1.00 | ALDH1A1 (0.35) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL1910858 | 0.81 | KDM4E (0.31) | ALDH1A1GAA | |
| SCHEMBL14902674 | 0.79 | ALDH1A1 (0.40) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL14902673 | 0.79 | ALDH1A1 (0.40) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL1910661 | 0.76 | KMT2A (0.38) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL319533 | 0.76 | KMT2A (0.38) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL1910662 | 0.76 | KMT2A (0.38) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL319367 | 0.73 | ALDH1A1 (0.34) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL1911105 | 0.70 | ALDH1A1 (0.36) | ALDH1A1HTTGAAMAPTCYP1A2 | |
| SCHEMBL1911109 | 0.70 | ALDH1A1 (0.36) | ALDH1A1HTTGAAMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |