Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239663 | 0.86 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLALOX15 | |
| SCHEMBL31735318 | 0.86 | USP2 (0.42) | USP2SMN1; SMN2RECQLDDB1CRBN | |
| SCHEMBL319828 | 0.85 | USP2 (0.48) | USP2SMN1; SMN2GPR119RECQLHRH3 | |
| SCHEMBL18053621 | 0.81 | USP2 (0.59) | USP2SMN1; SMN2GPR119RECQLALOX15 | |
| SCHEMBL2428542 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2GPR119RECQLDDB1 | |
| SCHEMBL139940 | 0.79 | MGLL (0.32) | — | |
| SCHEMBL17760306 | 0.78 | USP2 (0.46) | USP2SMN1; SMN2GPR119RECQLDDB1 | |
| SCHEMBL4278413 | 0.77 | USP2 (0.54) | USP2SMN1; SMN2GPR119RECQLHRH3 | |
| SCHEMBL156363 | 0.77 | USP2 (0.56) | USP2SMN1; SMN2GPR119RECQLHPGD | |
| SCHEMBL31685221 | 0.76 | USP2 (0.43) | USP2SMN1; SMN2GPR119RECQLALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590985-B1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LTD (IE) | 2014-05-14 | — | — | EP | disclosed |
| EP-2590985-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004400-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-01-12 | — | — | WO | disclosed |