SCHEMBL3198263

SCHEMBL3198263

O=C1NC(=O)C(S)(c2ccccc2)N1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.59
CACNA1F O60840 1/20 0.59
ALDH1A1 P00352 1/20 0.59
MAPT P10636 1/20 0.59
HTR2A P28223 1/20 0.59
HRH1 P35367 1/20 0.59
SCN1A P35498 1/20 0.59
SCN4A P35499 1/20 0.59
BLM P54132 1/20 0.59
PMP22 Q01453 1/20 0.59
CACNA1D Q01668 1/20 0.59
KCNH2 Q12809 1/20 0.59
CACNA1S Q13698 1/20 0.59
CACNA1C Q13936 1/20 0.59
SCN5A Q14524 1/20 0.59
SCN2A Q99250 1/20 0.59
SCN3A Q9NY46 1/20 0.59
AKR1B1 P15121 2/20 0.49
MMP2 P08253 1/20 0.48
MMP9 P14780 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenytoin SCHEMBL5499612 0.74 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL3440 0.74 CYP2C9 (1.00) CYP2C9CACNA1FALDH1A1MAPTHTR2A
SCHEMBL14354280 0.74 CYP2C9 (0.63) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL5160618 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2905857 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL2140317 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL10406406 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL29521348 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL157671 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A
Phenytoin SCHEMBL1461588 0.72 CYP2C9 (0.96) CYP2C9CACNA1FALDH1A1MAPTHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718437-B2 Method for analyzing N-terminal protein adducts ADDUCT ANALYS AB (SE) 2010-05-18 US disclosed
US-20100029013-A1 Methods for Detecting Asymmetric Dimethylarginine in a Biological Sample NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-02-04 US disclosed
US-7611844-B2 Methods for detecting asymmetric dimethylarginine in a biological sample BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY (US) 2009-11-03 US disclosed
EP-1738177-B1 METHOD FOR ANALYZING N-TERMINAL PROTEIN ADDUCTS ADDUCT ANALYS AB (SE) 2009-02-11 EP disclosed
US-20070190659-A1 Method for analyzing n-terminal protein adducts ADDUCT ANALYS AB (SE) 2007-08-16 US disclosed
EP-1738177-A1 METHOD FOR ANALYZING N-TERMINAL PROTEIN ADDUCTS Adduct Analys AB (SE) 2007-01-03 EP disclosed
WO-2005101020-A1 METHOD FOR ANALYZING N-TERMINAL PROTEIN ADDUCTS ADDUCT ANALYS AB (SE) 2005-10-27 WO disclosed
US-20040214252-A1 Methods for detecting asymmetric dimethylarginine in a biological sample NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-10-28 US disclosed
WO-2004046314-A2 METHODS FOR DETECTING ASYMMETRIC DIMETHYLARGININE IN A BIOLOGICAL SAMPLE THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2004-06-03 WO disclosed
US-6210928-B1 PRODUCING BOVINE GROWTH HORMONE HAVING AN N-TERMINUS ALANINE IN BACTERIA BY EXPRESSING A DNA SEQUENCE WITH CODON FOR N-TERMINUS ALANINE IMMEDIATELY DOWNSTREAM OF TRANSLATION START SIGNAL METHIONINE CODON MONSANTO COMPANY 2001-04-03 US disclosed
US-5744328-A GENETIC ENGINEERING MONSANTO COMPANY (US) 1998-04-28 US disclosed
US-5631131-A cDNA probes and antibodies for human methenyltetrahydrofolate synthetase UNIVERSITE DE MONTREAL (CA) 1997-05-20 US disclosed
EP-0458918-B1 METHOD FOR OBTAINING A RECOMBINANT PROTEIN AND ITS UTILIZATION IN THE ASSAY FOR THE AFRICAN SWINE PEST VIRUS (ASPV) UNIV OVIEDO (ES) 1997-05-07 EP disclosed
EP-0193515-B1 Method for obtaining biologically active bovine and porcine growth hormone and composition comprising biologically active porcine growth hormone MONSANTO CO (US) 1996-08-14 EP disclosed
US-5399489-A Production of proteins in procaryotes MONSANTO COMPANY (US) 1995-03-21 US disclosed
EP-0458918-A1 METHOD FOR OBTAINING A RECOMBINANT PROTEIN AND ITS UTILIZATION IN THE ASSAY FOR THE AFRICAN SWINE PEST VIRUS (ASPV) UNIVERSIDAD DE OVIEDO (ES) 1991-12-04 EP disclosed
US-5037806-A Enhancing lactation of cow with bovine growth hormone containing valine at 126 position MONSANTO COMPANY (US) 1991-08-06 US disclosed
US-4861868-A Production of proteins in procaryotes MONSANTO COMPANY (US) 1989-08-29 US disclosed
EP-0297068-A2 Mammal intestine hormone precursor KabiGen AB (SE) 1988-12-28 EP disclosed
US-4088751-A SHAVING CREAM, SHAMPOO, LOTION, 2-THIO-4-OXYPYRIMIDINE OR THIOHYDANTOIN AND HYDROGEN PEROXIDE, EXOTHERMIC REDOX REACTION COLGATE-PALMOLIVE COMPANY (US) 1978-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029013-A1 Methods for Detecting Asymmetric Dimethylarginine in a Biological Sample ADM2, PADI3, PADI4 CYP2C9 2439/4885CACNA1F 4689/4885ALDH1A1 866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.