Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL592796 | 0.91 | ALDH1A1 (0.58) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL29635769 | 0.91 | ALDH1A1 (0.58) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Hydrogen Sulfide SCHEMBL28290770 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Ammonia Solution, Strong SCHEMBL28249187 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL28270887 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL1504949 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| Water SCHEMBL28200366 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL1504946 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL10607069 | 0.89 | ALDH1A1 (0.56) | MAPTMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL1646477 | 0.84 | TSHR (0.56) | MAPTMEN1ALDH1A1KMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105272967-B | Triazines epidermal growth factor receptor inhibitor and its application | 南京圣和药业股份有限公司 | 2019-05-24 | — | — | CN | disclosed |
| CN-109280032-A | A kind of histon deacetylase (HDAC) inhibitor and its preparation method and application of pyridazinone mother nucleus structure | 中国科学院上海药物研究所 | 2019-01-29 | — | — | CN | disclosed |
| CN-107849045-A | Purine radicals N hydroxy pyrimidine carboxamides derivatives and its production and use | 贵州百灵企业集团制药股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105272967-A | Triazine epidermal growth factor acceptor inhibitor and application thereof | NANJING SANHOME PHARMACEUTICAL CO LTD | 2016-01-27 | — | — | CN | disclosed |
| CN-105175349-A | Phenyl substituted triazine compounds adopted as EGFR inhibitor, and applications thereof | NANJING SANHOME PHARMACEUTICAL CO LTD | 2015-12-23 | — | — | CN | disclosed |
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH | 2010-02-11 | — | — | US | disclosed |
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-12-04 | — | — | US | disclosed |
| WO-2008052075-A2 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-05-02 | — | — | WO | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
| EP-1773315-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006008558-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | PSEN2, PSEN1, NAT1 | MAPT 16/4885MEN1 4509/4885ALDH1A1 126/4885 |
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | HTR2C, HTR5A, NPY1R | MAPT 3925/4885MEN1 4176/4885ALDH1A1 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.