Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NPC1L1 | Q9UHC9 | 7/20 | 0.51 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318850 | 0.89 | MEN1 (0.53) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL318756 | 0.89 | NPC1L1 (0.61) | NPC1L1 | |
| SCHEMBL318851 | 0.87 | MEN1 (0.49) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL318727 | 0.84 | OPRL1 (0.53) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL318263 | 0.82 | MEN1 (0.55) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL16244620 | 0.82 | CYP2D6 (0.48) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL319458 | 0.82 | BDKRB2 (0.48) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL20187031 | 0.81 | OPRL1 (0.67) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL319102 | 0.81 | BDKRB2 (0.48) | MEN1CYP3A4CYP2D6KMT2ACYP2C9 | |
| SCHEMBL319383 | 0.79 | NPC1L1 (0.55) | NPC1L1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9156840-B2 | D2 antagonists, methods of synthesis and methods of use | Altos Therapeutics, LLC (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-11-27 | — | — | US | disclosed |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | MEN1 2011/4885CYP3A4 659/4885CYP2D6 250/4885 |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | MEN1 2011/4885CYP3A4 659/4885CYP2D6 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.