Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12101183 | 0.86 | FOLH1 (0.56) | SLC6A2SLC6A4SLC6A3ITGB1ITGA4 | |
| Lithium SCHEMBL3305736 | 0.85 | FOLH1 (0.55) | SLC6A2SLC6A4SLC6A3ITGB1ITGA4 | |
| SCHEMBL3305732 | 0.85 | FOLH1 (0.55) | SLC6A2SLC6A4SLC6A3ITGB1ITGA4 | |
| SCHEMBL3220302 | 0.84 | TSHR (0.45) | SLC6A2SLC6A4SLC6A3FOLH1TSHR | |
| SCHEMBL3215264 | 0.83 | HRH3 (0.47) | SLC6A2SLC6A4SLC6A3TSHRSRD5A2 | |
| SCHEMBL5937202 | 0.81 | ALDH1A1 (0.56) | SLC6A2SLC6A4SLC6A3FOLH1ALDH1A1 | |
| SCHEMBL3211520 | 0.80 | AOC3 (0.55) | — | |
| SCHEMBL5937377 | 0.80 | ALDH1A1 (0.51) | SLC6A2SLC6A4SLC6A3F10ALDH1A1 | |
| SCHEMBL27619926 | 0.79 | ALDH1A1 (0.54) | SLC6A2SLC6A4SLC6A3FOLH1ALDH1A1 | |
| SCHEMBL3205630 | 0.79 | TSHR (0.55) | ALDH1A1TSHRNPSR1TTRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | disclosed |
| US-20070004701-A1 | Topoisomerase inhibitors | PROPHARMACON, INC. (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004701-A1 | Topoisomerase inhibitors | TOP1, TOP2A, TOP2B | SLC6A2 3690/4885SLC6A4 3633/4885SLC6A3 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.