Oxindole

Oxindole

SCHEMBL3201159

COC(=O)CC1C(=O)Nc2ccccc21.O=C1Cc2ccccc2N1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.57
AHR P35869 1/20 0.49
PDK2 Q15119 1/20 0.49
HTT P42858 1/20 0.46
HSD17B10 Q99714 1/20 0.46
IDO1 P14902 8/20 0.44
TDO2 P48775 3/20 0.44
MAPT P10636 2/20 0.42
GAA P10253 2/20 0.42
KDM4E B2RXH2 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GSK3B P49841 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8998987 0.88 EGFR (0.72) EGFRHTTHSD17B10IDO1TDO2
Oxindole SCHEMBL1460829 0.85 AHR (0.54) EGFRAHRPDK2HSD17B10IDO1
Oxindole SCHEMBL5502041 0.84 AHR (0.58) AHRPDK2IDO1TDO2MAPT
SCHEMBL3201173 0.83 EGFR (0.65) EGFRHTTHSD17B10IDO1TDO2
SCHEMBL320134 0.77 IDO1 (0.57) EGFRHTTHSD17B10IDO1TDO2
SCHEMBL8999189 0.75 IDO1 (0.55) EGFRIDO1TDO2MAPTGAA
SCHEMBL28573090 0.75 MAPT (0.59) EGFRHSD17B10IDO1TDO2MAPT
Oxindole SCHEMBL8636427 0.74 AHR (0.64) AHRPDK2IDO1MAPTKDM4E
SCHEMBL5279457 0.74 IDO1 (0.59) EGFRIDO1TDO2MAPTGAA
SCHEMBL4334134 0.74 HSD17B10 (0.53) EGFRHTTHSD17B10MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119619358-A Metabolic marker for detecting novel coronavirus combined with Epstein-Barr virus infection and application thereof 湖北医药学院附属襄阳市第一人民医院 2025-03-14 CN disclosed
US-20100041900-A1 Isolation of lactam compound from adlay bran and its use on anti-proliferative cancer cells KUANG TA FOODS CO., LTD (TW) 2010-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041900-A1 Isolation of lactam compound from adlay bran and its use on anti-proliferative cancer cells MLX, BROX, TOP1 EGFR 544/4885AHR 3594/4885PDK2 3755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.