MLX

Max-like protein X · Q9UH92 · MLX on Sugi Atlas →

638 patent compounds predicted against MLX, 284 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL13393698 SCHEMBL13393698 0.77 1/20
SCHEMBL13393918 SCHEMBL13393918 0.77 1/20
SCHEMBL10207177 SCHEMBL10207177 0.73 1/20
SCHEMBL14144736 SCHEMBL14144736 0.61 1/20
SCHEMBL13380037 SCHEMBL13380037 0.56 1/20
SCHEMBL13393683 SCHEMBL13393683 0.56 1/20
SCHEMBL13393704 SCHEMBL13393704 0.56 1/20
SCHEMBL12105450 SCHEMBL12105450 0.56 1/20
SCHEMBL13380061 SCHEMBL13380061 0.56 1/20
SCHEMBL13393695 SCHEMBL13393695 0.56 1/20
SCHEMBL13393832 SCHEMBL13393832 0.56 1/20
SCHEMBL13393860 SCHEMBL13393860 0.56 1/20
SCHEMBL12205737 SCHEMBL12205737 0.55 1/20
SCHEMBL13380054 SCHEMBL13380054 0.55 1/20
SCHEMBL13380065 SCHEMBL13380065 0.55 1/20
SCHEMBL13951109 SCHEMBL13951109 0.55 1/20
SCHEMBL14209345 SCHEMBL14209345 0.55 1/20
SCHEMBL13393702 SCHEMBL13393702 0.55 1/20
SCHEMBL13393767 SCHEMBL13393767 0.55 1/20
SCHEMBL8610946 SCHEMBL8610946 0.54 1/20

Clinical trials — most relevant to MLX by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery PHASE4COMPLETED
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia PHASE3COMPLETED
TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis PHASE3COMPLETED
Evaluate the Efficacy and Safety of HLX10 in Combination With HLX07 in Patients With Advanced Head and Neck Tumors PHASE2UNKNOWN
A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis PHASE2COMPLETED
Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer PHASE1/PHASE2SUSPENDED
A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) PHASE2RECRUITING
Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer PHASE1/PHASE2WITHDRAWN
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy PHASE2RECRUITING
Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of HLX26 and HLX10 in Patients With Advanced/Metastatic Solid Tumor PHASE1COMPLETED
Gene Transfer Clinical Trial for Spinal Muscular Atrophy Type 1 PHASE1COMPLETED
Phase I Study of Cell Therapies for the Treatment of Patients With Relapsed or Refractory AML or High-risk MDS PHASE1UNKNOWN
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML) nanWITHDRAWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
X-chromosome Inactivation, Epigenetics and the Transcriptome nanCOMPLETED
Study of the Sex Differences in Inflammatory Diseases in Children nanUNKNOWN
A Study to Assess Variation in Potential Biomarkers in Friedreich Ataxia nanCOMPLETED
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic nanCOMPLETED
Study of Selected X-Linked Disorders: Aicardi Syndrome nanRECRUITING
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
Gene x Behavior Interaction in the Look AHEAD Study nanCOMPLETED
Amyotrophic Lateral Sclerosis (ALS) Families Project nanRECRUITING
Epidemiology of Atherosclerosis nanCOMPLETED
Patient-derived Glioma Stem Cell Organoids nanACTIVE_NOT_RECRUITING
Studying Chromosomes in Samples From Younger Patients With Neuroblastoma nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Correlation Between PT and INR to Factor 7 nanUNKNOWN
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43 nanUNKNOWN
Improvements in Aerobic Fitness With Exercise Training: the Role of Myokines nanCOMPLETED
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate? nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a MLX binder may also engage these)

ProteinNameSimilarity
O08609 1.000 O08609 →
MORF4L1 Mortality factor 4-like protein 1 0.950 landscape →
APBA1 Amyloid-beta A4 precursor protein-binding fam 0.947 landscape →
P60762 0.946 P60762 →
Q6DN14 0.945 Q6DN14 →
P52161 0.943 P52161 →
E9PV86 0.941 E9PV86 →
Q6A039 0.941 Q6A039 →
Q6P5H6 0.941 Q6P5H6 →
M0R7T9 0.940 M0R7T9 →
X2JAU8 0.940 X2JAU8 →
Q64705 0.940 Q64705 →
B2RYF1 0.940 B2RYF1 →
Q15853 0.940 Q15853 →
B2RUJ5 0.940 B2RUJ5 →
Q63665 0.940 Q63665 →
Q8BKR5 0.939 Q8BKR5 →
O35430 0.939 O35430 →
Q5RD33 0.938 Q5RD33 →
A4IGK3 0.938 A4IGK3 →
P52162 0.937 P52162 →
Q96IK1 0.937 Q96IK1 →
Q5BJU6 0.936 Q5BJU6 →
P28574 0.936 P28574 →
Q642H2 0.936 Q642H2 →
D4ABL6 0.935 D4ABL6 →
O60347 0.935 O60347 →
Q8K4G5 0.935 Q8K4G5 →
Q5SQY2 0.934 Q5SQY2 →
P52164 0.934 P52164 →