SCHEMBL3201276

SCHEMBL3201276

COC(=O)C1OC1c1ccc(OC)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.52
TSHR P16473 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.45
EDNRA P25101 2/20 0.45
EDNRB P24530 1/20 0.45
MAPT P10636 2/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
CES2 O00748 2/20 0.42
CES1 P23141 2/20 0.42
TP53 P04637 1/20 0.42
HPGD P15428 1/20 0.42
MAOA P21397 1/20 0.42
PTGS2 P35354 1/20 0.42
GABRA1 P14867 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7141149 1.00 BACE1 (0.52) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL8573735 1.00 BACE1 (0.52) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL3201279 1.00 BACE1 (0.52) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL8856846 1.00 BACE1 (0.52) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL8503544 1.00 BACE1 (0.52) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL15446338 0.88 BACE1 (0.46) BACE1TSHRMAPTALDH1A1LMNA
SCHEMBL15446214 0.87 TSHR (0.53) BACE1TSHRSMN1; SMN2EDNRAEDNRB
SCHEMBL7906596 0.86 TSHR (0.54) BACE1TSHRMAPTALDH1A1CA1
SCHEMBL7902731 0.86 TSHR (0.54) BACE1TSHRMAPTALDH1A1CA1
SCHEMBL7906590 0.86 TSHR (0.54) BACE1TSHRMAPTALDH1A1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10975260-B2 Monomers, polymers and coating formulations that comprise at least one N-halamine precursor, a cationic center and a coating incorporation group UNIVERSITY OF MANITOBA (CA) 2021-04-13 US claimed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US claimed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP claimed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US claimed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP claimed
CN-104023996-A METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP 2014-09-03 CN claimed
WO-2014030106-A2 PROCESS FOR PREPARATION OF OPTICALLY ACTIVE (2R,3S)-3-(4- METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER AND CIS LACTAM AND USES THEREOF UNIMARK REMEDIES LTD. (IN) 2014-02-27 WO claimed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO claimed
US-5756809-A ADDITION OF ORTHO-AMINOTHIOPHENOL ONTO 3-(4'-METHOXYPHENYL)-GLYCIDIC ACID METHYL ESTER IN THE PRESENCE OF ALKALI METAL SALTS OF WEAK ACIDS AND IN THE PRESENCE OF CATALYTIC AMOUNTS OF IRON COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1998-05-26 US claimed
JP-2693248-B2 1997-12-24 JP claimed
EP-0779811-A1 MYOCARDIAL PROTECTION USING BENZOTHIAZEPINONES UNIVERSITE DE MONTREAL (CA) 1997-06-25 EP claimed
EP-0773213-A2 Method for the preparation of methyl (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4\"-methoxyphenyl)propionate BAYER AG (DE) 1997-05-14 EP claimed
WO-1996007415-A1 MYOCARDIAL PROTECTION USING BENZOTHIAZEPINONES UNIVERSITE DE MONTREAL (CA) 1996-03-14 WO claimed
US-5274300-A Patent withdrawn after O.G. published SEPRACOR, INC. (US) 1993-12-28 US claimed
EP-0440723-A4 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS 1992-05-20 EP claimed
EP-0440723-A1 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS. SEPRACOR INC (US) 1991-08-14 EP claimed
WO-1990004643-A1 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS SEPRACOR, INC. (US) 1990-05-03 WO claimed
US-4908469-A Contacting a 2-aminothiophenol with an optically active 3-(4-alkyloxyphenyl)glycidic acid acyclic alkyl ester MARION LABORATORIES, INC. (US) 1990-03-13 US claimed
EP-0342902-A2 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines MARION LABORATORIES, INC. (a Delaware corporation) (US) 1989-11-23 EP claimed
JP-6335399-A None JP disclosed
JP-10304875-A None JP disclosed
US-12362387-B2 Carbon fiber battery electrodes with ionic liquid and gel electrolytes THE MITRE CORPORATION (US) 2025-07-15 US disclosed
US-20240363897-A1 CARBON FIBER BATTERY ELECTRODES WITH IONIC LIQUID AND GEL ELECTROLYTES THE MITRE CORPORATION (US) 2024-10-31 US disclosed
US-11978855-B2 Carbon fiber battery electrodes with ionic liquid and gel electrolytes THE MITRE CORPORATION (US) 2024-05-07 US disclosed
US-11879038-B2 Supramolecular gel supported on open-cell polymer foam UNIVERSITE DE STRASBOURG (FR) 2024-01-23 US disclosed
US-20220407107-A1 CARBON FIBER BATTERY ELECTRODES WITH IONIC LIQUID AND GEL ELECTROLYTES THE MITRE CORPORATION (US) 2022-12-22 US disclosed
US-11456483-B2 Carbon fiber battery electrodes with ionic liquid and gel electrolytes THE MITRE CORPORATION (US) 2022-09-27 US disclosed
EP-4028518-A1 SUPRAMOLECULAR GEL SUPPORTED ON OPEN-CELL POLYMER FOAM Université de Strasbourg (FR) 2022-07-20 EP disclosed
WO-2021048199-A1 SUPRAMOLECULAR GEL SUPPORTED ON OPEN-CELL POLYMER FOAM UNIVERSITÉ DE STRASBOURG (FR) 2021-03-18 WO disclosed
EP-3789427-A1 SUPRAMOLECULAR GEL SUPPORTED ON OPEN-CELL POLYMER FOAM Université de Strasbourg (FR) 2021-03-10 EP disclosed
US-20200287240-A1 Carbon Fiber Battery Electrodes With Ionic Liquid and Gel Electrolytes THE MITRE CORPORATION (US) 2020-09-10 US disclosed
US-10301397-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2019-05-28 US disclosed
US-20160340447-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2016-11-24 US disclosed
US-9458270-B2 Method for producing polydienes and polydiene copolymers with reduced cold flow BRIDGESTONE CORPORATION (JP) 2016-10-04 US disclosed
EP-2780177-B1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP (JP) 2016-03-23 EP disclosed
US-20140296445-A1 Method For Producing Polydienes And Polydiene Copolymers With Reduced Cold Flow BRIDGESTONE CORPORATION (JP) 2014-10-02 US disclosed
EP-2780177-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW Bridgestone Corporation (JP) 2014-09-24 EP disclosed
CN-104023996-A METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORP 2014-09-03 CN disclosed
WO-2014030106-A2 PROCESS FOR PREPARATION OF OPTICALLY ACTIVE (2R,3S)-3-(4- METHOXYPHENYL)GLYCIDIC ACID METHYL ESTER AND CIS LACTAM AND USES THEREOF UNIMARK REMEDIES LTD. (IN) 2014-02-27 WO disclosed
WO-2013075074-A1 METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW BRIDGESTONE CORPORATION (JP) 2013-05-23 WO disclosed
US-7671238-B2 Arylamino-arylpropanolamine derivatives and methods of their use WYETH LLC (US) 2010-03-02 US disclosed
US-7629400-B2 Image making medium HYMAN SYDNEY 2009-12-08 US disclosed
US-20090099164-A1 Phenylaminopropanol Derivatives and Methods of Their Use WYETH (US) 2009-04-16 US disclosed
US-7517899-B2 Phenylaminopropanol derivatives and methods of their use WYETH (US) 2009-04-14 US disclosed
US-20090093469-A1 Phenylaminopropanol Derivatives and Methods of Their Use WYETH (US) 2009-04-09 US disclosed
WO-2008042362-A1 ARYLAMINO-ARYLPROPANOLAMINE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-04-10 WO disclosed
US-20080085938-A1 Arylamino-Arylpropanolamine Derivatives and Methods of Their Use WYETH (US) 2008-04-10 US disclosed
EP-1732887-B1 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) WYETH CORP (US) 2008-01-09 EP disclosed
WO-2007073847-A1 NOVEL POLYPEPTIDE HAVING ESTERASE ACTIVITY AND RECOMBINANT ESTERASE AND USE THEREOF DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) 2007-07-05 WO disclosed
US-7220870-B2 Hydrolytic kinetic resolution of cyclic substrates PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2007-05-22 US disclosed
US-7220870-B2 Hydrolytic kinetic resolution of cyclic substrates PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2007-05-22 US disclosed
EP-1732887-A1 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) Wyeth (US) 2006-12-20 EP disclosed
EP-1676614-A1 Continuous process for the enantioselective enrichment and separation of enantiomers using centrifugal separation DSM IP Assets B.V. (NL) 2006-07-05 EP disclosed
WO-2005097744-A1 1-(1H-INDOL-1-YL)-3-(4-METHYLPIPERAZIN-1-YL)-1-PHENYL PROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE NOREPINEPHRINE (NE) AND THE SEROTONINE (5-HT) ACTIVITY AND THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) WYETH (US) 2005-10-20 WO disclosed
US-20050222148-A1 Phenylaminopropanol derivatives and methods of their use WYETH (US) 2005-10-06 US disclosed
EP-1115881-B1 PROCESS FOR THE ENZYMATIC KINETIC RESOLUTION OF 3-PHENYLGLYCIDATES BY TRANSESTERIFICATION WITH AMINOALCOHOLS ZAMBON SPA (IT) 2005-03-30 EP disclosed
US-6528531-B1 Coccidiosis in poultry; MERCK & CO., INC. 2003-03-04 US disclosed
US-20030035917-A1 Image making medium HYMAN SYDNEY (US) 2003-02-20 US disclosed
US-6521445-B1 Stereoselective ester hydrolysis of racemic trans-3-(4-methoxyphenyl) glycidic acid ester using a hydrolase enzyme; resolution; diltiazem production SEPRACOR, INC. 2003-02-18 US disclosed
US-6451587-B1 ASYMMETRIC REDUCTION OF A KETONE TO AN ALCOHOL, WHICH COMPRISES: CONTACTING THE KETONE WITH A MICROORGANISM, OR AN ENZYME REDUCTION SYSTEM CAPABLE OF ACCOMPLISHING THE SUBJECT REDUCTION COMPRISING AN ENZYME DERIVED FROM SAID MICROORGANISM PFIZER INC. 2002-09-17 US disclosed
EP-1115881-A1 PROCESS FOR THE ENZYMATIC KINETIC RESOLUTION OF 3-PHENYLGLYCIDATES BY TRANSESTERIFICATION WITH AMINOALCOHOLS ZAMBON GROUP S.p.A. (IT) 2001-07-18 EP disclosed
US-6197953-B1 ESTER INTERCHANGE, CRYSTALLIZATION, ISOMERIZATION; PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES TANABE SEIYAKU CO., LTD. (JP) 2001-03-06 US disclosed
US-6187936-B1 TRANSESTERIFICATION OF MIXTURE OF TRANS ENANTIOMERS CATALYSED BY ENZYMES IN ORGANIC SOLVENT WITH AMINOALCOHOLS TO GIVE MIXTURE OF TRANS ESTERS, NON TRANSESTERIFIED AND TRANSESTERIFIED, HAVING OPPOSITE CONFIGURATION, SEPARATING ZAMBON GROUP S.P.A. (IT) 2001-02-13 US disclosed
WO-2000017384-A1 PROCESS FOR THE ENZYMATIC KINETIC RESOLUTION OF 3-PHENYLGLYCIDATES BY TRANSESTERIFICATION WITH AMINOALCOHOLS ZAMBON GROUP S.P.A. (IT) 2000-03-30 WO disclosed
EP-0988297-A2 PROCESS FOR PREPARING OPTICALLY ACTIVE PHENYLOXIRANE COMPOUNDS Tanabe Seiyaku Co., Ltd. (JP) 2000-03-29 EP disclosed
US-5998637-A CRYSTALLIZATION; SEPARATION TANABE SEIYAKU CO., LTD. (JP) 1999-12-07 US disclosed
WO-1998056762-A2 PROCESS FOR PREPARING OPTICALLY ACTIVE PHENYLOXIRANE COMPOUNDS TANABE SEIYAKU CO., LTD. (JP) 1998-12-17 WO disclosed
US-5847122-A Process for preparing 1,5-benzothiazepine derivative TANABE SEIYAKU CO., LTD. (JP) 1998-12-08 US disclosed
JP-H10304875-A NEW LIPASE PROTEIN SHIONOGI & CO LTD 1998-11-17 JP disclosed
EP-0861834-A1 Process for preparing optically active trans-3-substituted glycidic acid ester TANABE SEIYAKU CO., LTD. (JP) 1998-09-02 EP disclosed
US-5756809-A ADDITION OF ORTHO-AMINOTHIOPHENOL ONTO 3-(4'-METHOXYPHENYL)-GLYCIDIC ACID METHYL ESTER IN THE PRESENCE OF ALKALI METAL SALTS OF WEAK ACIDS AND IN THE PRESENCE OF CATALYTIC AMOUNTS OF IRON COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1998-05-26 US disclosed
US-5756809-A ADDITION OF ORTHO-AMINOTHIOPHENOL ONTO 3-(4'-METHOXYPHENYL)-GLYCIDIC ACID METHYL ESTER IN THE PRESENCE OF ALKALI METAL SALTS OF WEAK ACIDS AND IN THE PRESENCE OF CATALYTIC AMOUNTS OF IRON COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1998-05-26 US disclosed
EP-0657544-B1 Process for preparing optically active glycidate esters SEPRACOR INC (US) 1997-12-29 EP disclosed
EP-0792876-A2 Process for preparing 1,5-benzothiazepine derivative TANABE SEIYAKU CO., LTD. (JP) 1997-09-03 EP disclosed
EP-0609031-B1 Process for preparing benzothiazepine derivatives SHIONOGI & CO (JP) 1997-08-13 EP disclosed
EP-0779811-A1 MYOCARDIAL PROTECTION USING BENZOTHIAZEPINONES UNIVERSITE DE MONTREAL (CA) 1997-06-25 EP disclosed
EP-0773213-A2 Method for the preparation of methyl (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4\"-methoxyphenyl)propionate BAYER AG (DE) 1997-05-14 EP disclosed
EP-0773213-A2 Method for the preparation of methyl (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4\"-methoxyphenyl)propionate BAYER AG (DE) 1997-05-14 EP disclosed
US-5580867-A Myocardial protection during ischemia and reperfusion UNIVERSITE DE MONTREAL (CA) 1996-12-03 US disclosed
EP-0446771-B1 Esterase from Serratia and process for preparing the same TANABE SEIYAKU CO (JP) 1996-06-19 EP disclosed
WO-1996007415-A1 MYOCARDIAL PROTECTION USING BENZOTHIAZEPINONES UNIVERSITE DE MONTREAL (CA) 1996-03-14 WO disclosed
EP-0417785-B1 Process for preparing optically active 3-phenylglycidic acid esters TANABE SEIYAKU CO (JP) 1995-12-06 EP disclosed
EP-0470575-B1 Improved process for producing esterase TANABE SEIYAKU CO (JP) 1995-11-15 EP disclosed
US-5466838-A Catalytic reaction of olefin with oxygen in the presence of aldehyde SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-11-14 US disclosed
EP-0540009-B1 Process for producing epoxides SUMITOMO CHEMICAL CO (JP) 1995-08-30 EP disclosed
EP-0440723-B1 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS SEPRACOR INC (US) 1995-08-16 EP disclosed
EP-0657544-A1 Process for preparing optically active glycidate esters SEPRACOR, INC. (US) 1995-06-14 EP disclosed
EP-0395302-B1 Process for preparing 1,5-benzothiazepine derivatives TANABE SEIYAKU CO (JP) 1995-01-04 EP disclosed
JP-H06335399-A PRODUCTION OF OPTICALLY ACTIVE ESTER OF TRANS-3-PHENYLGLYCIDIC ACID AND PRODUCTION OF BENZO(THI)AZEPINE DSM NV 1994-12-06 JP disclosed
US-5367087-A Process for producing epoxide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-22 US disclosed
EP-0362556-B1 Method for preparing optically active 3-phenylglycidic acid esters TANABE SEIYAKU CO (JP) 1994-11-02 EP disclosed
EP-0612737-A1 Process for preparing 1,5-benzothiazepine derivatives TANABE SEIYAKU CO., LTD. (JP) 1994-08-31 EP disclosed
US-5274300-A Patent withdrawn after O.G. published SEPRACOR, INC. (US) 1993-12-28 US disclosed
US-5273897-A Production of an esterase in a culture medium containing an ester of sorbitan or polyoxyethylene sorbitan and a fatty acid along with an amino acid TANABE SEIYAKU CO., LTD. (JP) 1993-12-28 US disclosed
EP-0302379-B1 NAPHTHOTHIAZEPINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME TANABE SEIYAKU CO., LTD. (JP) 1993-09-29 EP disclosed
US-5244803-A Stereoselective hydrolysis by microorganism in culture TANABE SEIYAKU CO., LTD. (JP) 1993-09-14 US disclosed
EP-0540009-A1 Process for producing epoxides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-05-05 EP disclosed
US-5208156-A Hydrolytic enzymes for carboxylic esters TANABE SEIYAKU CO., LTD. (JP) 1993-05-04 US disclosed
US-5198557-A PROCESS FOR THE RESOLUTION OF 3-(4-SUBSTITUTED-PHENYL)-GLYCIDIC ACID DERIVATIVES ZAMBON GROUP S.P.A. (IT) 1993-03-30 US disclosed
US-5169779-A Enzyme catalyzing the transesterification of dextrorotatory enantiomer into insoluble form by adding acid, salt or ester derivative of butanol SYNTHELABO (FR) 1992-12-08 US disclosed
EP-0498706-A1 Process for the preparation of (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)methylpropionate SYNTHELABO (FR) 1992-08-12 EP disclosed
EP-0153692-B1 METHOD FOR ISOMERIZATION A GLYCIDATE DERIVATIVE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1992-07-29 EP disclosed
US-5128469-A Catalytic ring closure with organic sulfonic acid; amidation TANABE SEIYAKU CO., LTD. (JP) 1992-07-07 US disclosed
EP-0440723-A4 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS 1992-05-20 EP disclosed
EP-0353032-B1 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS Sankyo Company Limited (JP) 1992-02-26 EP disclosed
EP-0470575-A1 Improved process for producing esterase TANABE SEIYAKU CO., LTD. (JP) 1992-02-12 EP disclosed
US-5055575-A Process for preparing 1,5-benzothiazepine derivatives TANABE SEIYAKU CO., LTD. (JP) 1991-10-08 US disclosed
EP-0446771-A2 Esterase from Serratia and process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 1991-09-18 EP disclosed
EP-0440723-A1 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS. SEPRACOR INC (US) 1991-08-14 EP disclosed
US-5002942-A Calcium channel blockers for cardiovascular disorders SANKYO COMPANY, LIMITED (JP) 1991-03-26 US disclosed
EP-0417785-A1 Process for preparing optically active 3-phenylglycidic acid esters TANABE SEIYAKU CO., LTD. (JP) 1991-03-20 EP disclosed
EP-0342902-A3 2-HYDROXY-PROPANOIC ACID ACYCLIC ALKYL ESTERS FOR BENZOTHIAZEPINES MARION LABORATORIES, INC. (a Delaware corporation) (US) 1991-01-30 EP disclosed
US-4950663-A N-DESMETHYL, DEACETYL DILTIAZEM DUMONT LOUIS (CA) 1990-08-21 US disclosed
EP-0206662-B1 THIAZOLIDINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME Tanabe Seiyaku Co., Ltd. (JP) 1990-05-09 EP disclosed
WO-1990004643-A1 PROCESS FOR PREPARING OPTICALLY ACTIVE GLYCIDATE ESTERS SEPRACOR, INC. (US) 1990-05-03 WO disclosed
EP-0362556-A1 Method for preparing optically active 3-phenylglycidic acid esters TANABE SEIYAKU CO., LTD. (JP) 1990-04-11 EP disclosed
US-4908469-A Contacting a 2-aminothiophenol with an optically active 3-(4-alkyloxyphenyl)glycidic acid acyclic alkyl ester MARION LABORATORIES, INC. (US) 1990-03-13 US disclosed
US-4908469-A Contacting a 2-aminothiophenol with an optically active 3-(4-alkyloxyphenyl)glycidic acid acyclic alkyl ester MARION LABORATORIES, INC. (US) 1990-03-13 US disclosed
EP-0353032-A1 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders Sankyo Company Limited (JP) 1990-01-31 EP disclosed
US-4885375-A Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters MARION LABORATORIES, INC. (US) 1989-12-05 US disclosed
EP-0342902-A2 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines MARION LABORATORIES, INC. (a Delaware corporation) (US) 1989-11-23 EP disclosed
EP-0342902-A2 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines MARION LABORATORIES, INC. (a Delaware corporation) (US) 1989-11-23 EP disclosed
EP-0342903-A1 Improved resolution of 3-(4-methoxyphenyl)-glycidic acid with in situ conversion to alkyl esters MARION LABORATORIES, INC. (a Delaware corporation) (US) 1989-11-23 EP disclosed
EP-0338893-A2 Process for the preparation of (+)-(2S,3S)-3-(2-aminophenyl) thio-2-hydroxy-3-(4-methoxyphenyl) propionic acid methylester SYNTHELABO (FR) 1989-10-25 EP disclosed
US-4810705-A BENZODIAZEPINE DERIVATIVE ANTAGONISTS SANOFI (FR) 1989-03-07 US disclosed
EP-0182273-B1 1,5-BENZOTHIAZEPINE DERIVATIVES, A PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS AS WELL AS THE USE THEREOF Tanabe Seiyaku Co., Ltd. (JP) 1989-03-01 EP disclosed
EP-0302379-A1 Naphthothiazepine derivatives and a process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 1989-02-08 EP disclosed
EP-0158339-B1 1,5-BENZOTHIAZEPHINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS Tanabe Seiyaku Co., Ltd. (JP) 1989-01-18 EP disclosed
US-4777178-A CARDIOTONIC AGENTS TANABE SEIYAKU CO., LTD. (JP) 1988-10-11 US disclosed
EP-0098892-B1 PROCESS FOR PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES Tanabe Seiyaku Co., Ltd. (JP) 1987-10-28 EP disclosed
US-4689327-A N-substituted-2-[2-[2-(4-phenylpiperazine-1-yl)ethoxy]phenyl]-thiazolidine-3-carboxamides useful as cardiotonic agent TANABE SEIYAKU CO., LTD. (JP) 1987-08-25 US disclosed
US-4665068-A HYPOTENSIVES, VASODILATORS TANABE SEIYAKU CO., LTD. (JP) 1987-05-12 US disclosed
EP-0206662-A1 Thiazolidine derivatives and process for preparing the same Tanabe Seiyaku Co., Ltd. (JP) 1986-12-30 EP disclosed
US-4621150-A METAL PERHALATE OR SULFONATE OR COMPLEX; GLYCIDATE, 2-HYDROXY-3-BUTENOATE, EPOXIDE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1986-11-04 US disclosed
EP-0182273-A1 1,5-Benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof Tanabe Seiyaku Co., Ltd. (JP) 1986-05-28 EP disclosed
US-4585768-A ANTICOAGULANTS TANABE SEIYAKU CO., LTD. (JP) 1986-04-29 US disclosed
EP-0167355-A2 Thiazolidine derivative and processes for preparing the same Tanabe Seiyaku Co., Ltd. (JP) 1986-01-08 EP disclosed
EP-0158339-A2 1,5-Benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions Tanabe Seiyaku Co., Ltd. (JP) 1985-10-16 EP disclosed
EP-0153692-A2 Method for isomerization a glycidate derivative SAGAMI CHEMICAL RESEARCH CENTER (JP) 1985-09-04 EP disclosed
EP-0059335-B1 NOVEL PROCESS FOR PREPARING THREO-2-HYDROXY-3-(4-METHOXYPHENYL)-3-(2-NITROPHENYLTHIO)-PROPIONIC ESTER Tanabe Seiyaku Co., Ltd. (JP) 1985-05-15 EP disclosed
EP-0098892-A1 Process for preparing 1,5-benzothiazepine derivatives Tanabe Seiyaku Co., Ltd. (JP) 1984-01-25 EP disclosed
US-4420628-A Process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester TANABE SEIYAKU CO., LTD. (JP) 1983-12-13 US disclosed
US-4416819-A Process for preparing 1,5-benzothiazephine derivatives TANABE SEIYAKU CO., LTD. (JP) 1983-11-22 US disclosed
EP-0059335-A1 Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester Tanabe Seiyaku Co., Ltd. (JP) 1982-09-08 EP disclosed
EP-0059335-A1 Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester Tanabe Seiyaku Co., Ltd. (JP) 1982-09-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099164-A1 Phenylaminopropanol Derivatives and Methods of Their Use PAH, PNMT, COMT BACE1 3618/4885TSHR 3880/4885SMN1; SMN2 184/4885
US-20050222148-A1 Phenylaminopropanol derivatives and methods of their use PAH, PNMT, COMT BACE1 3618/4885TSHR 3880/4885SMN1; SMN2 184/4885
US-20080085938-A1 Arylamino-Arylpropanolamine Derivatives and Methods of Their Use PNMT, PAH, SLC18A2 BACE1 3681/4885TSHR 2696/4885SMN1; SMN2 322/4885
US-20090093469-A1 Phenylaminopropanol Derivatives and Methods of Their Use PAH, PNMT, COMT BACE1 3618/4885TSHR 3880/4885SMN1; SMN2 184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.