Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201336 | 0.77 | PIM1 (0.44) | PIM1NOTUMPRKD3PRKCGPRKCB | |
| SCHEMBL3086867 | 0.69 | KMT2A (0.43) | PIM1NOTUMALDH1A1TSHRAPP | |
| SCHEMBL3086865 | 0.68 | KMT2A (0.42) | PIM1NOTUMALDH1A1TSHRAPP | |
| SCHEMBL20777927 | 0.68 | PIM1 (0.39) | PIM1NOTUMMAOBPRKD3PRKCG | |
| SCHEMBL28637737 | 0.66 | ALDH1A1 (0.44) | PIM1NOTUMMAOBPRKD3PRKCG | |
| SCHEMBL31717960 | 0.66 | RAB9A (0.47) | NOTUMALDH1A1TSHRAPPKMT2A | |
| SCHEMBL16179948 | 0.66 | RAB9A (0.47) | NOTUMALDH1A1TSHRAPPKMT2A | |
| SCHEMBL13232183 | 0.64 | GAA (0.44) | ALDH1A1 | |
| SCHEMBL10761116 | 0.64 | BRD4 (0.44) | PIM1 | |
| SCHEMBL29929810 | 0.63 | MAPT (0.43) | NOTUMALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795255-B2 | Rigidified compounds for modulating heparanase activity | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2010-09-14 | — | — | US | disclosed |
| US-20080039456-A1 | Rigidified Compounds for Modulating Heparanase Activity | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2008-02-14 | — | — | US | disclosed |
| EP-1846383-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | Insight Biopharmaceuticals Ltd. (IL) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006072953-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039456-A1 | Rigidified Compounds for Modulating Heparanase Activity | HPSE, HEXA, GAA | PIM1 3637/4885NOTUM 1211/4885GRK5 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.