Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149825 | 0.90 | KCNH2 (0.46) | KCNH2SLC2A1TOP2A | |
| SCHEMBL3150681 | 0.90 | KCNH2 (0.51) | KCNH2SLC2A1TOP2A | |
| SCHEMBL3209294 | 0.83 | KCNH2 (0.40) | KCNH2NR1H4 | |
| SCHEMBL19470012 | 0.82 | TOP2A (0.44) | KCNH2NR1H4TOP2A | |
| SCHEMBL3201907 | 0.80 | KCNH2 (0.44) | KCNH2SLC2A1 | |
| SCHEMBL3154490 | 0.79 | KCNH2 (0.51) | KCNH2SLC2A1TOP2A | |
| SCHEMBL3150250 | 0.79 | KCNH2 (0.71) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL3223961 | 0.79 | KCNH2 (0.70) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL3205588 | 0.79 | KCNH2 (0.70) | KCNH2TOP2A | |
| SCHEMBL3099943 | 0.76 | KCNH2 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048544-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE-DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048544-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE-DERIVATIVES FOR TREATING TUBERCULOSIS | NQO2, MT-ND1, SDHB | KCNH2 784/4885SLC2A1 4630/4885NR1H4 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.