MT-ND1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8492838	0.52	4/20
SCHEMBL8492845	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL8493191	0.55	3/20
SCHEMBL8493327	0.55	3/20

Clinical trials — most relevant to MT-ND1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)	PHASE1/PHASE2	NOT_YET_RECRUITING
Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease	PHASE1/PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling	nan	ACTIVE_NOT_RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Survey on Supplement Use in Mitochondrial Disease	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Red Light Ptosis Proof-of-Concept	nan	UNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
Development of a New Technique for Quantifying Mitochondrial DNA in Single Muscle Fibers	nan	NOT_YET_RECRUITING
Mitoquines in COPD	nan	UNKNOWN
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
mtDNA Mutation Load Analysis in Mesoangioblasts	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a MT-ND1 binder may also engage these)

Protein	Name	Similarity
Q8M889	—	1.000	Q8M889 →
Q96126	—	1.000	Q96126 →
O78695	—	1.000	O78695 →
Q9T9Z0	—	1.000	Q9T9Z0 →
Q9T9X9	—	1.000	Q9T9X9 →
O78694	—	1.000	O78694 →
O03850	—	1.000	O03850 →
Q9T9W3	—	0.999	Q9T9W3 →
P92690	—	0.999	P92690 →
Q94VI4	—	0.998	Q94VI4 →
Q70Y28	—	0.997	Q70Y28 →
P24968	—	0.997	P24968 →
Q70Y30	—	0.997	Q70Y30 →
Q8M881	—	0.996	Q8M881 →
Q8M892	—	0.996	Q8M892 →
P41296	—	0.996	P41296 →
Q94VC3	—	0.995	Q94VC3 →
Q9ZXY4	—	0.995	Q9ZXY4 →
O78698	—	0.995	O78698 →
O79427	—	0.994	O79427 →
Q96189	—	0.994	Q96189 →
Q8M893	—	0.994	Q8M893 →
P24967	—	0.993	P24967 →
Q9ZZZ1	—	0.992	Q9ZZZ1 →
Q8M891	—	0.992	Q8M891 →
Q70Y23	—	0.991	Q70Y23 →
O78696	—	0.991	O78696 →
Q8M888	—	0.991	Q8M888 →
Q8M867	—	0.991	Q8M867 →
O78711	—	0.991	O78711 →