Sugi Predict

Sugi Predict / Compounds / SCHEMBL3202503

SCHEMBL3202503

SCHEMBL3202503

COC1CCN(c2cccc(S(=O)(=O)n3cc(C4=CCC(N)CC4)c4ncccc43)c2)C1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 12/20 0.35
▸ PDE10A Q9Y233 1/20 0.34
▸ HTR1A P08908 2/20 0.34
▸ DRD2 P14416 2/20 0.34
▸ HTR2A P28223 2/20 0.34
▸ HTR7 P34969 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ DRD3 P35462 1/20 0.34
▸ FFAR2 O15552 1/20 0.34
▸ IDH1 O75874 2/20 0.33
▸ MET P08581 2/20 0.33
▸ NR1H2 P55055 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3206593 0.89 HTR6 (0.34) HTR6PDE10AHTR1ADRD2HTR2A
SCHEMBL3215933 0.88 HTR6 (0.34) HTR6PDE10AHTR1ADRD2HTR2A
SCHEMBL4114138 0.87 HTR6 (0.49) HTR6HTR1ADRD2HTR2AHTR7
SCHEMBL3336322 0.87 HTR6 (0.49) HTR6HTR1ADRD2HTR2AHTR7
SCHEMBL3625746 0.86 HTR6 (0.48) HTR6HTR1ADRD2HTR2AHTR7
SCHEMBL3340412 0.86 HTR6 (0.48) HTR6HTR1ADRD2HTR2AHTR7
SCHEMBL3224187 0.83 IDH1 (0.37) HTR6FFAR2IDH1METNR1H2
SCHEMBL3337331 0.82 HTR6 (0.54) HTR6NR1H2NR1H3
SCHEMBL3202675 0.80 HTR6 (0.49) HTR6HTR1ADRD2HTR2AHTR7
SCHEMBL3203525 0.80 HTR6 (0.41) HTR6FFAR2IDH1METNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010024980-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — WO claimed
US-20100056491-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — US claimed
WO-2010024980-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — WO disclosed
WO-2010024980-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — WO disclosed
US-20100056491-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — US disclosed
US-20100056491-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — US disclosed
US-20100056491-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY MEMORY PHARMACEUTICALS CORPORATION (US) 2010-03-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100056491-A1 4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY HTR6, HTR4, HTR3B HTR6 1/4885PDE10A 345/4885HTR1A 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.